On the internal administration of nitrate of silver, and on the occurrence of a blue line upon the gums as the earliest sign of argyria / by William Pepper.

Date:
1877
Catalogue details

Licence: Public Domain Mark

Credit: On the internal administration of nitrate of silver, and on the occurrence of a blue line upon the gums as the earliest sign of argyria / by William Pepper. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    ON THE INTERNAL ADMINISTRATION OF NITRATE OF SILVER, AND ON THE OCCURRENCE OF A BLUE LINE UPON THE GUMS AS THE EARLIEST SIGN OF ARGYRIA. By WILLIAM PEPPER, A.M., M.I)., PROFESSOR OF CLINICAL MEDICINE IN THE UNIVERSITY OF PENNSYLVANIA. [Read March 7, 1877.] It is of course not within the province of the present article to discuss the very numerous and varied conditions in which the internal administration of nitrate of silver is strongly indicated. Suffice it to say that there are few remedial agents whose thera- peutic value and range of application are equally ex- tensive. This is not surprising when it is remembered that nitrate of silver possesses a peculiarly valuable local action in addition to its power of directly affect- ing the nervous system by absorption. The topical action of nitrate of silver, given internally, even in small doses, may be said to extend throughout the entire gastro-intestinal tract, with, perhaps, the excep- tion of the rectum. In addition to this, it appears to me to be established by clinical evidence that a certain amount of influence is produced on the continuation of the duodenal mucous membrane into the common hepatic duct, and possibly into the pancreatic duct. This local action is in part that of an astringent, but