Immunological relations of a chicken sarcoma / Wm. H. Woglom.

  • Woglom, William Henry, 1879-1953.
Date:
1914
Catalogue details

Licence: In copyright

Credit: Immunological relations of a chicken sarcoma / Wm. H. Woglom. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [Reprinted from Proceedings N.S., Vol. XI IMMUNOLOGICAL WM. H. WOGLOM, M.D. (I rani Columbia University, George Crocker Special Research Fund, F. C. Wood, Director.) Ilie employment of such terms as “sarcoma” and “tumor” throughout this paper is to be regarded rather as a concession to convenience than as indicating the possession of any definite idea regarding the material in question. The growth used in the following experiments is the first of that class to be reported by Dr. Peyton Rous, to whose courtesy our laboratory is indebted for the fowl from which the transplantations were made. Because of the conflicting opinions regarding the nature of this tumor, it is a matter of some interest to ascertain whether chickens can be made resistant to it by previous treatment with embryonic fowl tissue, after the manner in which mice can be rendered refractory to mouse tumors with the embryonic material of their species. A series of fowls were injected with hashed chicken embryo in amounts of from one to ten cubic centimeters, and inoculated with the sarcoma at periods varying from five to forty days later. Three weeks after the implantation of the tumor they were autopsied. No reliable evidence of immunity was observed, as reference to the table will show. Since three treated chickens out of eight in the first group did not develop tumors, the experiment was repeated with double the amount of embryonic tissue; at the second trial the result was clean cut, none of the treated chickens being found resistant. The three other instances in which treated fowls did not develop tumors are probably chance occurrences, a view which is strengthened by the fact that Rous, also, has re- corded quite recently his failure to immunize against this tumor.