The transference of immunity from ewe to lamb / by T. Dalling, J.H. Mason, and W.S. Gordon.

  • Dalling, Thomas.
Date:
[1928?]
Catalogue details

Licence: In copyright

Credit: The transference of immunity from ewe to lamb / by T. Dalling, J.H. Mason, and W.S. Gordon. Source: Wellcome Collection.

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    2 Dailing—Mason—Gordon : Transference of Immunity Table I.—Antitoxin in Serum of Injected Sheep. Sheep Before injection After first injection After second injection (in days) 40 Nil P. 1 7 P. 3 24 P. 3 34 P?3 41 Nil P. 1 17 nil 24 nil 44 nil 42 Nil P. 1 17 P. 2 24 P. 1 44 P. 1 43 Nil Nil 3 P. 2 21 P. 3 32 nil 44 Nil Nil 14 nil 21 nil 33 nil 45 Nil Nil 17 P. 3 24 P. 1 44 nil 46 Nil Nil f4 nil 21 nil 44 nil 47 Nil Nil 23 P. 2 28 P.2 54 nil 48 Nil Nil 25 P. 1 32 nil 50 nil 49 Nil Nil 16 nil 24 nil 44 nil Tests done in mice i. v. 0-2 c.c. serum mixed with one or more M.L. Ds.toxin and stood for about one hour before injecting1. Nil — no protection. 7 P.8, etc. = protection against 3 M.L.Ds. toxin when test done with serum got seven days after second injection, etc. Testing of Lamb's Serum for Antitoxin and a Comparison with Antitoxin Co?itent of the Mother Sheep. Again, many samples of lamb’s serum have been tested for antitoxin content. Table II is the result of testing samples of serum from lambs produced by the ewes referred to in Table I. Samples of blood were drawn on the day of the lamb’s birth and again when the lamb was 7-9 days old. The results of the test indicate that the antitoxin content of the lamb’s serum corresponded closely to that of the mother sheep. Our experiments do not indicate whether such antitoxin was developed by the foetus in utero or whether it was transmitted to the foetus in utei'o by the mother or via the colostrum after birth. Experiments will be carried out during this year’s lambing season to establish this point. Table II.—Comparison Mother Ewe and Lamb Serum—Presence of Antitoxin. No. ewe and lambs 41 42 43 44 45 46 47 48 Lamb serum (day of birth) Nil (a) No P. (5) P. 3 (c) P. 3 f (a) Nil i (b) Nil (a) Nil (b) Nil / (a) P. 3 t (b) P. 3 (a) Nil (b) Nil {a) Nil (5) Nil P. 2 Lamb serum (7-9 days old) Died P. 3 P. 3 Ewe serum (day of birth of lambs Nil P. 2 - 1 - 1 P.3 } Nil > Nil \ P. 2 | P.2 f P. 2 P. 2 Nil P. 3 Nil P. 2 P. 1 Tests done in mice i. v. 0-2 c.c. serum mixed with one or more M.L.Ds. toxin and stood for about one hour before injecting. Nil = No protection—all mice died. P. 3, etc. = protected mice against 3 M.L.Ds. toxin, etc. John Bale, Sons and Danielsson, Ltd., 83-91, Great Tifchfield Street, London, W. 1.