Diet and canine hysteria : experimental production by treated flour [preliminary report] / by Sir Edward Mellanby.

  • Mellanby, Edward, Sir, 1884-1955
Date:
[1946?]
Catalogue details

Licence: In copyright

Credit: Diet and canine hysteria : experimental production by treated flour [preliminary report] / by Sir Edward Mellanby. Source: Wellcome Collection.

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    It is seen from Table I that during the first period of 24 weekb dog 3175, receiving untreated flour, had no hysteria or fits, whilia 3177, which received the treated flour, had 30 attacks of varioui kinds. During the second period, lasting 12 weeks, when th types of flour were reversed, dog 3175 suffered from 24 attach and 3177 had none. Table II Dog No. Type of Flour Time to First Attack Hysteria Hysteri¬ cal Fits Epilepti¬ form Fits Probable Fits Tota/ 1 3187* Treated 4 weeks 5 7 3 1 16 3188 4 „ 4 9 0 4 17 3189 Untreated 0 0 0 0 0 j 3190t Treated 4 weeks 4 13 6 4 27 3191 4 „ 5 11 3 21 r Untreated 0 0 6 0 0 (1st 15 3192 J weeks) m (« Treated 2 weeks 2 2 0 1 5 1' (8 weeks) I ! —1 * Died after 23 weeks on diet after having a severe epileptiform fit. t Died after 15 weeks on diet after having continuous epileptiform fits f 36 hours. Table II also shows how definite is the effect of the agenize flour. The one dog of the litter having the untreated cere t throughout, No. 3189, had no hysterical bouts or fits during tl p experimental period of 22 weeks, whereas the four haviu treated flour all the time had attacks varying in severity ar ranging in number from 16 to 27 during this period. The la of the series, No. 3192, whose diet was changed in the course m the experiment, had no fits during the 15 weeks it received u: treated flour, but two weeks after the substitution of treatu (agenized) flour the attacks started, and it had five of them. $ Vitamin A Deficiency and Canine Hysteria Canine hysteria can be superimposed on vitamin A deficien t when animals have a diet deficient in vitamin A and containir: agenized flour. Examples are seen in Table III, which sho^ the results of an experiment made on four dogs of the sar litter, two of which had the basal diet described above, co taining 2,000 i.u. of vitamin A daily, and the other two had t a same diet with the omission of the vitamin. No hysteria ; fits developed in any of the dogs during the 15 weeks wh<t untreated flour was given, whether vitamin A was included | the diet or not. In the second period treated (agenized) flol was substituted for the untreated type in each case, and <| four animals suffered to some extent from hysteria or fi though the vitamin A content of the diet remained the sar as during the first period. After 10 days on this diet untreat; flour was again given to two of the animals—Nos. 3203 an 3205—the first being vitamin-A-deficient and the other norm The flour has now been changed for one month, but, exce? during the first day, neither dog has had any form of fit, ai #