Lobsters, lymph and histamine-liberation / by W.D.M. Paton.

  • Paton, William D. M.
Date:
1959
Catalogue details

Licence: In copyright

Credit: Lobsters, lymph and histamine-liberation / by W.D.M. Paton. Source: Wellcome Collection.

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    89 International Archives of Allergy and Applied Immunology Redactores: R.R. A. Coombs-Cambridge - D. Harley-London - P. Kallos- Helsingborg - W. Kaufman-Bridgeport, Conn. - W. Loffler-Ziirich. BASEL (Schweiz) S. KARGER NEW YORK Separatum Vol. 15, No, 1-3 Printed in Switzerland Paton, W. D. M.: Int. Arch. Allergy 15: 35—46 (1959). Lobsters, Lymph and Histamine-Liberation By W. D. M. Baton Department of Pharmacology, Royal College of Surgeons of England, London Introduction In 1891, Heidenhain described experiments on the formation of lymph in which he characterised lymphagogues of the first and second orders; the first caused a secretion of a concentrated lymph, and included materials such as decoctions of crustacean muscle; the second promoted a flow of dilute lymph, and included saline solutions. He took the view that the lymphagogues of the first order stimulated endothelial cells to active “secretion” of lymph. Starlings in 1894, took up the subject in the light of his studies on formation of tissue fluid. He rejected the conception of active secretion, and produced convincing evidence that first order lymphagogues acted simply by damaging capillary permeability and by increasing capillary flow. These materials were then left as capillary poisons of an unspecified character. Heidenhain's observations are, however, suggestive in another direction. He describes how he came to test crustacean muscle as follows: ‘Tch hatte um die Zeit meiner Beschaftigung mit diesen Dingen zufallig Gelegenheit, den von Pathologen oft beschriebenen Aus- bruch von Nesselquaddeln nach Krebsgenuss selbst zu beobachten. Fraulein A. B. bekam bald, nachdem sie einige Krebse gegessen, nicht bloss Urticaria in gewohnlicher Form, sondern dabei ein starkes diffuses Hautodem in der linken Halsgegend, welches vom Unterkiefer bis fast zum Schliisselbein reichte und mehrere Stunden stehen blieb. Diese Beobachtung gab Anlass zu folgendem V ersuche’ ’.