A note on external applications of creasote in the treatment of malarial intermittent fevers / by Leonard Rogers.

  • Rogers, Leonard, 1868-1962.
Date:
[1896?]
Catalogue details

Licence: Public Domain Mark

Credit: A note on external applications of creasote in the treatment of malarial intermittent fevers / by Leonard Rogers. Source: Wellcome Collection.

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    fAcbicAL Csft'zjziTt? ,tan ]§90.j ROGERS ON CREASOTE IN THE TREATMENT OP MALARIAL FEVERS. 11 kmc examine 1 her 24 h mrs after the operations, Hn,| t\ ml in or she* had no fever, told her to show ht*i side which she said was swollen and painful. Unfortunately for her she showed the right side instead of the left, and her deceit was discovered the first inoculation is always given on the R.ft side). Although she limped in her walk, and feigned pain on pressure, she had to ac¬ knowledge that she had made a mistake. Sup¬ posing this question had arisen a week later, when the local symptoms would have dis¬ appeared, there would have been no evidence by which to test her statement, except her name in the register, about which there was some question. A second case to the same effect :—Dr. Haff- kine had just finished the reinoculations on a Certain garden in Cachar ; a few days later it was authentically reported that a coolie belong¬ ing to the garden who had been twice operated upon had died of cholera. The manager was absent from the garden when the report was made, but on his return he tried to find the man’s name in the inoculation register, and failing, made personal enquiries from which it appeared that the coolie had never been inocu¬ lated, but that his relations had spread the report hoping to gain some advantage, and their word had been taken as correct by the hospital assistant who reported it. Had the man been permanently marked, it would have lessened the risk of such a mistake, and it shows ho\y essential it is where the results of the inoculations are to be watched, to feep accurate registersof the inocu¬ lated, in the absence of a more permanent record. The 1 ength of time which may lapse between i the first and second inoculations has not yet been decided. On two gardens in South Sylhet, the coolies were reinoculated after a lapse of six to seven months without unusually severe effects. Dr. Haffkine when testing the microbe to be used for the second vaccine in Cachar, inoculated himself after an interval of two years with about three times the ordinary dose . water). He had, I think, been inoculated twice previously ; his temperature taken at the time of the operation was 96'8°F., and 12 hours later it had risen to 10F4° or 4 6° of fever. The swelling at (he seat of inoculation after an interval of a week or ten days, reappeared as a circumscribed painful lump, which was gradually absorbed. The M icrobes.—The microbes for the first vaccine were of the same race as had been attenuated in Europe some eight years pre¬ viously ; the cultures were characteristic, and it showed no tendency to degenerate. It, was • • ■ © not, however, till the beginning of April that a microbe suitable for the second vaccine was finmd ; the one which had been in use hitherto had shown signs of involution, and Dr. Haffkine had abandoned it hoping to find another which Would be healthy, and mure suitable for the i meal operations than one of foreign origin. another were rarely made, and most of the I attempts to isolate the microbe were made from ! the dejecta. Commas from three different sources were isolated :— 1. The Karkoori microbe was taken from the jejunum of a woman who died of what was described b}T Dr. Powell of Kallein as cholera of a virulent type ; under the microscope it was small but characteristic. As a test of its viru¬ lence o-V of an agar culture of 24 hours’ growth | was injected into the peritoneum of a guinea- pig weighing between 350 to 400 grammes. The animal did not die. 2. The Silchar microbe was isolated from a very feculent stool two days’ old taken from a man who did not die. The test guinea-pig weighed *f48 grammes • of a tube was injected into the peritoneal cavity, and the auimal died in 14 hours. 3. A microbe was isolated from a ease of cholera at Badarpur in a child who recovered. It was discarded, as not likely to be strong. The choice of a microbe for the second vaccine lay between Nos. 1 and 2 The former had cer¬ tain advantages, and it had been strongly recom- mended by Dr. Powell as a virulent microbe, but the test dose had failed to kill a guinea-pig. The Silchar microbe which had proved fatal was therefore chosen, and three preliminary passages were made to raise it to the “ fixed strength.0 Dr. Haffkine inoculated himself with a culture from the second passage and the Kurkoori, Digobar and Hathall coolies were inoculated with cultures from the third passage. As the microscopical appearance of this microbe was not satisfactory it was abandoned in favour of the Kurkoori microbe, which was used for all the subsequent operations. Dr. Haffkine isolated these microbes without the aid of peptone. Small quantities of cholera dejecta were placed in cups (previously boiled and covered with paper), diluted with an equal quantity of water, and put aside in a warm place ; the microbe was found in colonies in the surface film in from 10 to 24 hours. A NOTE ON EXTERNAL APPLICATIONS OF CREASOTE IN THE TREATMENT OF malarial intermittent fevers * By Leonard Rogers, m.b.. b.s. (Lond.), f.r.c.s, (Eng.), Surgn.-Lieut., I.M.S. A paper by Dr. Carterf on the antipyretic effect of external applications of creasote or guaiacol first suggested to me their use in the treatment of cases of intermittent fevers in which the temperature is high. Their action in producing free perspiration and at the same * Towards the expenses of this research a praut was made by the British Me Real Association on the recom* mendation of the Scientific Grants Committee of the Asso¬ ciation.