Experimental Notebook

File contains a Yale notebook, used after Vane had left Yale, with the title on the cover, "J.R.V. Notes". The volume is undated but the last references to journal articles are from 1964 which would probably date the notebook to between 1956 and 1964. The volume contains a series of notes including the following:

Diagrams of the chemical structures of nucleic acid bases (undated).

Notes on R.N.A and D.N.A and their functions (undated).

Notes on the biosynthesis of purines.

Diagrams of the chemical structures of pyrimidines (undated).

Notes, including chemical structures, on the functions of naturally occurring adenine dinucleotides & substituted mononucleotides.

Notes on the blood brain barrier.

Notes on a series of articles including the following:

J.J. Jaffe, R.E. Handschumacher & A.D. Welch, "Studies on the Carcinostatic Activity in Mice of 6-Azauracil Riboside (Azauridine), In Comparison with that of 6-Azauracil", Yale Journal of Biology and Medicine, vol.30 no.3, p168-175, December 1957.

C.A. Pasternak & R.E. Handschumacher, "Biochemical Activity of 6-Azauridine: Interference with Pyrimidine Metabolism in Transplantable Mouse Tumors ", Journal of Biological Chemistry, vol.234, p2992-2997, November 1959.

A.D. Welch, R.E. Handschumacher & J.J. Jaffe, "Studies on the pharmacology of 6-Azauracil", The Journal of Pharmacology and Experimental Therapeutics, vol.129 no.3, p262-270, July 1960.

S.S. Cardoso, P. Calabresi & R.E. Handschumacher, "Alterations in Human Pyrimidine Metabolism as a Result of Therapy with 6-Azauridine", Cancer Research, vol.21, p1551-1556, 1 December 1961.

R.L. Volle, R.E. Green, L. Peters, R.E. Handschumacher & A.D. Welch, "Renal Tubular Excretion Studies With Pyrimidine Derivatives and Analogs", Journal of Pharmacology, vol.136 no.3, p353-360, June 1962.

W. Wells, D. Gaines & H. Koenig, "Studies of Pyrimidine Nucleotide Metabolism in the Central Nervous System", Journal of Neurochemistry, vol.10 no.10, p709-723, (1963).

J.H. Laragh, P.J. Cannon & R.P. Ames, "Interaction Between Aldosterone Secretion, Sodium and Potassium Balance, and Angiotensin Activity in Man: Studies in Hypertension and Cirrhosis", Canadian Medical Association Journal, vol.90 no.4, p248-256, 25 January 1964.

J. Bing & J. Kazimierczak, "Renin Content of Different Parts of the Juxtaglomerular Apparatus. 4. Localization of Renin in the Kidney.", Acta Pathology Microbiolology Scandinavia, vol.54, p80-84, (1962).