Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale.

  • Barger, George, 1878-1939.
Date:
1910
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    ethylamino-bases in each of the two classes, (a) and (6), in which they have been examined generally, come next in order of activity ; but the order of the bases other than the methylamino-bases varies with the uterus employed. With the virgin organ, which gives a purely in- hibitor response to stimulation of the hypogastric nerves, the order is, almost invariably, methylamino, ethylamino, amino, propylamino. In class (6) this, it will be remembered, is also the order of the pressor activities; but the superiority of the methylamino-base of class (a) in inhibitor action is especially noteworthy in view of its markedly inferior At A, 0-25 O.O. rrrjr amino-aceto-catechol. 1UO g () ,, methylamino-aceto-catechol. Fresh Itinger at C, C. pressor activity as compared with the ethylamino- and amino-bases of that class. With the non-pregnant but multiparous organ a different order is frequently observed. On such an organ the inhibitor action of the amino-bases is usually very slight, and it may even be replaced by a very weak augmentor effect on the tonus, the methylamino-bases still causing profound inhibition. In such a case as the last-mentioned it is usually found that the inhibitor action of the ethylamino-bases is also comparatively weak, and, in one such case, that of the ethyl- amino-ketoue was distinctly inferior to that of the propylamino-ketone.