Preliminary trials of bistrimethylammonium decane and pentane diiodide (C10 and C5) in man / Geoffrey Organce, W.D.M. Paton, E.J. Zaimis.

  • Organe, Geoffrey, Sir.
Date:
[1949?]
Catalogue details

Licence: In copyright

Credit: Preliminary trials of bistrimethylammonium decane and pentane diiodide (C10 and C5) in man / Geoffrey Organce, W.D.M. Paton, E.J. Zaimis. Source: Wellcome Collection.

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    noticed subjectively was on the eyes and eyelids, within 20 sec. of the beginning of the injection. Paralysis reached a maximum in about 4 min., recovery beginning in about 10 min. and being complete in 1 or 2 hours. Paralysis began in the eyelids, ocular muscles, and facial muscles, and later affected the neck, trunk, and limbs. The degree of paralysis varied within limits among the subjects ; at the peak of the paralysis two of them were incapable of moving their limbs or head at all, and had virtually complete paralysis of hand strength (figs. 1 and 2) ; the third was very consider¬ ably weakened, and his hand strength fell by about 60%. In all cases there was a considerable reduction in abdominal tone and in the power of contracting the abdominal muscles. The respiration, however, was not embarrassed, though the vital capacity was diminished at the peak of the paralysis by about 35%. Speech was impaired, the voice becoming weaker and lower in Fig. I. Fig. 7. Figs. I and 2—Paralysis and return of hand strength.