Bone marrow transplantation present and future.

UK : University of London, 1976.

1 encoded moving image (28 min.) : sound, black and white

00:27:59

University of London

Some restrictions

CC-BY-NC

In English

Presented by Professor J.G. Humble, Consultant Haematologist, Westminster Medical School. Produced by David Sharp.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Prof. Humble introduces the subject and talks about the current interest in the use of bone marrow transplantation to treat severe aplastic anaemia and immune diseases of infancy and early childhood. He gives a history of research in this area, beginning with Neumann's research in 1868. An illustration shows where bone marrow can be taken for transplantation. He discusses the importance of the totipotential stem cell. Diagrams explain stem cell function. An electron micrograph of a stem cell is seen, and Humble discusses the stem cell. Time start: 00:00:00:00 Time end: 00:04:15:00 Length: 00:04:15:00

Segment 2 Humble then discusses trials using cancer patients' bone marrow to treat them after radiation. A graph shows the single successful case of the study. The graph details the patient's recovery, which Humble also describes. He talks about residual immunity, which must be destroyed to allow grafts to take. A table lists information on the methods of destroying residual immunity. He also discusses the danger of graft-versus-host disease. A table lists the syndromes of this disease, and two pictures of people suffering from the disease are seen. Time start: 00:04:15:00 Time end: 00:09:27:00 Length: 00:05:12:00

Segment 3 Humble lists the conditions needed for bone marrow transplantation. A photograph of a baby with SCID is seen, along with a list of symptoms of the condition. Further photographs of the little girl are seen as she recovers. Humble describes the bone marrow transplants from her brother. Time start: 00:09:27:00 Time end: 00:14:05:20 Length: 00:04:38:20

Segment 4 Next, Humble describes the steps taken to set up a bone marrow transplant. Animated diagrams show the steps. Humble describes the decontamination process of the patient, and footage of a boy in a sterile plastic environment is seen. Time start: 00:14:05:20 Time end: 00:18:24:00 Length: 00:04:18:05

Segment 5 Humble continues describing the steps taken to set up a bone marrow transplant. He discusses how to destroy the patient's immunity. Photographs of the required surgical equipment are seen. The transplant is described. Time start: 00:18:24:00 Time end: 00:23:06:00 Length: 00:04:42:00

Segment 6 Next, Humble talks about how to support the patient in the post-graft period. He then talks about future developments and what he hopes will improve in this field. This includes treatment for congenital haemolytic disease. Time start: 00:23:06:00 Time end: 00:27:59:02 Length: 00:04:53:02