The diagnostic value of hemolysis in cases of cancer / R. Ottenberg and A.A. Epstein.

  • Ottenberg, Reuben, 1882-1959.
Date:
1909
Catalogue details

Licence: In copyright

Credit: The diagnostic value of hemolysis in cases of cancer / R. Ottenberg and A.A. Epstein. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    eyte suspension used by Crile, which has not been published, but which Dr. Crile was kind enough to communicate to us by letter, was given up, after having been tried in sixty-nine cases, because of the inconstant results. The nature of the results can best be appreciated by reference to the accompanying tables. The intensity of the hemolysis in each test is indicated approximately by the number of plus marks. The horizontal columns represent sera, the vertical columns the corresponding blood cells. It will be noticed that even strongly hemolytic sei'a seldom lake more than half of the different varieties of red blood cells with which they are mixed. In doing the experiments, it should be said, the tubes were numbered by another person in such a way that the person who made the readings was not aware which blood he was examining. The results, as a whole, without regard to the intensity of the reac- tion or the number of different kinds of red cells hemolysed by each serum, may be summarized as follows: Of the 100 subjects 38 were suffering from malignant tumors, 40 had other diseases and 22 were apparently healthy. (The diagnosis in nearly all of the tumor cases was confirmed by operation and microscopic report. The diagnosis in the other cases rested generally on clinical data.) In the 38 cases of malignant tumor, 28 patients had serum which was hemolytic—a proportion of 76 per cent. In the 40 other diseases, 20 patients had hemolytic sera (50 per cent.). Of these, 6 were cases of tuberculosis—a well-recognized cause of isohemolysis; 5 of the 6 sera were hemolytic. If we exclude the tuberculous cases, 15 cases, that is 42 per cent., of the 35 remaining cases of disease were hemolytic. The diagnoses in these cases were as follows: Cases 151 and 75.—Fibroadenoma of breast (two cases). Case 95.—Catarrhal jaundice. Case 94.—Chronic gastritis (?). Case 108.—Postpartum general infectio^n. Case 124.—Postoperative adhesions (gall bladder). Case 138.—Diffuse lipoma. Case 147.—Subacute bacterial endocarditis and streptococcemia. Case 162.—Diabetes mellitus. Case 164.—Endocarditis (chronic). Case 169.—Appendicitis. Case 178.—Colloid goiter. Case 180.—Plumbism. Case 185.—Hodgkin’s disease. Case 127.—Chronic thyroiditis (tuberculous). Of the 22 normal persons, 1 showed hemolysis (5 per cent.) This was a patient who had been operated on for hernia several weeks before and in whom no signs or symptoms of any disease could be elicited.