Diabetes mellitus : its pathological chemistry and treatment / by Carl von Noorden; translated by Florence Buchanan and I. Walker Hall.

  • Noorden Carl von, 1858-1944.
Date:
1907
Catalogue details

Licence: In copyright

Credit: Diabetes mellitus : its pathological chemistry and treatment / by Carl von Noorden; translated by Florence Buchanan and I. Walker Hall. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    power of assimilation for Isevulose than for grape- sugar. C. DIABETIC HYPERGLYCEMIA AND GLYCOSURIA I. Diminution in the Amount of Sugar Destruction (a) Poverty of Glycogen in the Organs.—In follow- ing out the behaviour of the carbohydrates in the body of a diabetic we are at once struck not only by the already mentioned hyperglycjemia, but also by the fun- damental fact of the extraordinai*y poverty of the organs in glycogen. Thesfe observations were first made on the post-mortem tissues of diabetics. The puncture of the liver of the living diabetic has con- firmed them. Later, the experimental results of pan- creas extirpation pointed to the same condition. Every time a marked diabetes was induced in an animal by successful total extirpation of the pancreas, the liver and the muscles were found to be almost entirely free from glycogen, even when glucose or starch had been administered to the animals shortly before death. New observations made in my laboratory on the liver and muscles removed from the body immediately after death have fully confirmed these experimental results. E. Pfliiger has lately attempted to criticise and to depreciate the observations hitherto made by bringing forward a few cases in which the liver contained large quantities of glycogen after death. These were evi- dently cases of not very severe diabetes; though the patients died, it was more as the result of complications