The influence of an antihistamine drug on the release of histamine in the unanaesthetized dog / by W.D.M. Paton and M. Schachter.

  • Paton, William D. M.
Date:
[1951?]
Catalogue details

Licence: In copyright

Credit: The influence of an antihistamine drug on the release of histamine in the unanaesthetized dog / by W.D.M. Paton and M. Schachter. Source: Wellcome Collection.

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    that the therapeutic usefulness of these drugs under such circumstances may lie entirely in their ability to interfere with actions of histamine subsequent to its release, whereas the release itself is not interfered with. The remarkable phenomenon of temporary complete refractoriness to a histamine liberator merits further investigation. For example, it would be of interest to know whether or not protection against a liberator such as Compound 48/80 confers resistance to other conditions associated with histamine release. In this way it might prove possible to determine whether histamine is liberated by different mechanisms under different conditions. Our experiments do not distinguish the possible processes involved in this refractoriness, such as the decrease in available histamine, a reduced “ sensitivity ” of the tissues, or the development of protective autacoid mechanisms. Summary The histamine liberator Compound 48 / 80 is capable of releasing large amounts of histamine in the unanaesthetized dog. Although signs associated with histamine release, such as facial swelling and itchiness, are almost completely eliminated by mepyramine, the amount of histamine released, as determined by the amount of gastric secretion, is not reduced. Repeated administration of Compound 48/80 produces a temporary state of complete refractoriness to the same dose of the drug. References Baltzly, R., Buck, J. S., de Beer, E. J., and Webb, F. J. (1949). J. Amer. chem. Soc., 71, 1301. Feldberg, W. (1941). Ann. Rev. Physiol., 3, 671. Grossman, M., and Robertson, C. R. (1948). Proc. Soc. exp. Biol., N.Y., 68, 550. Krantz, J. C., Carr, C. J., Bird, J. G., and Cook, S. (1948). J. Pharmacol., 93, 188. Lourie, E. M., and York, W. (1939). Ann. trop. Med. Parasit., 33, 289. Macintosh, F. C., and Paton, W. D. M. (1949). J. Physiol., 109, 190. Paton, W.D. M. (1951). Brit. J. Pharmacol., 6, 499. Reuse, J. J. (1948). Brit. J. Pharmacol., 3, 174. Ricketts, W. E., Kirsner, J. B., and Palmer, W. L. (1949). Amer. J. med. Sci., 217, 539. Schild, H. O. (1947). Brit. J. Pharmacol., 2, 189. Staub, H. (1946). Helv. physiol, pharmacol. Acta, 4, 539. Wells, J. A., Morris, H. C., and Dragstedt, C. A. (1946). Proc. Soc. exp. Biol., N.Y., 61, 104. Woodward, E. R., Dragstedt, L. R., Tovee, E. G., Oberhelman, H. A., and Neal, W. B. (1948). Proc. Soc. exp. Biol., N.Y., 67, 350.