Selected monographs on dermatology / P.G. Unna [and others].

Date:
1893
Catalogue details

Licence: Public Domain Mark

Credit: Selected monographs on dermatology / P.G. Unna [and others]. Source: Wellcome Collection.

    536/636 (page 518)
    A portion transferred to a watch-glass is treated with ; few drops of dilated hydrochloric acid, evaporated to dry ness below 1200 F., the residue dissolved in a few drops o water, and then a drop of highly dilute solution of ferrii chloride added (free from acid). There will be developec a fine blue colour. A drop of nitric acid upon another por tion of the residue will produce an orange or red colour destroyed by sulphide of ammonium. A few drops of Froehde's reagent (concentrated sul phuricacid containing, in each cubic centimetre, o'oi grm. o molybdate of sodium or ammonium) brought in contact wit! even traces of morphine assume at once a magnificen violet colour, which soon turns green, brownish green, an< yellow, becoming bluish violet after twenty-four hours. Treatment.—On account of the exceedingly evanescen character of the opium eruption, treatment is unnecessary Bromide of potassium is said to prevent the irritant effect of this drug upon the skin. PHOSPHORUS—ACIDUM PHOSPHORICUM. The stimulating effect of phosphorus upon the cutaneou circulation, producing flushings and other evidences of peri pheric capillary expansion, is well known. More decide* evidences of irritative action upon the skin occasional! follow its use. A bullous eruption has been sometime observed. According to Farquharson and Ringer, purpura some times occurs as a symptom of its toxic action, and is usuall developed in connection with gastro-intestinal derangemen PHENACETIN. The occurrence of an exanthern following the ingestion of this coal-ti derivative has heen reported by Valentin. An anaemic woman, who ha taken bromide and antipyrin for headache without much result, was give six decigrammes of phenacetin on two successive evenings. This cause great heat in the face. Eight days later a dose of one gramme was given i night, and two hours afterwards there was flushing of the face, an erytk matous general exanthern, most marked on the arms and legs, and ne: morning a temperature of 386° C. The skin lesions were not larger tha lentils, in part acuminate, and darker in the centre. There was no itchin: and the rash disappeared on the following day.—T. C. F.