Selected monographs on dermatology / P.G. Unna [and others].

Date:
1893
Catalogue details

Licence: Public Domain Mark

Credit: Selected monographs on dermatology / P.G. Unna [and others]. Source: Wellcome Collection.

    527/636 (page 509)
    Tests for Iodoform. To separate iodoform from the urine it is best to subject the latter to brisk distillation, taking care to use a cold con- denser. The distillate is tested in the same manner as directed for chloroform (see chloral) by applying the isonitril reaction. In addition, it is necessary to recognise the iodine swollen, and the seat of intense pruritus and burning. The symptoms recurred on touching the sores, after an interval, with ethereal solution of iodoform. There was no systemic reaction. Campbell Pope dressed an inflamed bursa of the arm on three separate occasions, at intervals, with (i) iodoform gauze, (2) again with iodoform gauze, (3) with iodoform ointment. After each dressing an eczema-like dermatitis attacked the whole limb, Taylor dusted a bubo cavity with iodoform and stuffed it with plain gauze, retained by a spica bandage. On the following day an erythematous rash had spread nearly to the umbilicus and half way down the thigh. There was no systemic reaction. Marcus Beck dressed with iodoform a wound made by the removal of an atrophic scirrhus of the breast. Forthwith, an eczematous dermatitis spread continuously over the whole side of the thorax. Taylor dusted iodoform freely on some rupial ulcers on the left leg of a man in wretched health and bandaged the limb. Local irritation arose at once, and next day a deep red erythematous eruption had spread from the leg to the thigh, coincident with systemic poisoning. A scarlatiniform erythema appeared about the neck and shoulders, increased rapidly, merged with the invading eiythema of the thigh, and in forty-eight hours covered the whole body. Wallich dressed a finger with iodoform for a month. Dermatitis then set in locally, subsequently attacked the other hand, and a rubeolar rash appeared on the forearm, arm, thorax, and abdomen. Janovsky dressed an ulcerated gumma of the left calf with iodoform, and in three days there was ephemeral febrile disturbance and dermatitis of the left thoracic region, the back and the left shoulder blade. The same observer dusted some iodoform over soft chancres. Febrile reaction occurred in two days, and an erythema appeared on the thighs, the right hypogastrium and lumbar region, extended to the left side, and then invaded the forearms. This experience was repeated. Gerlach dressed an ulcer of the leg with iodoform ointment (5i t° 33) spread on lint and bandaged. A few hours later the whole leg was swollen and the seat of bullous dermatitis. In twenty-four hours there was enormous swelling of the face, temples, and ears. In forty-eight hours there was swelling and papular eczema on the forearms, arms, neck, and upper third of the chest, and back. The Petechial Form.—Janovsky applied iodoform to a scraped lupus patch of the right thigh of a girl. Three days later purpuric spots appeared over the surrounding skin, and continued to develop as high up as the breasts. Fourteen days later the drug was reapplied with a similar result —T. C. F.