Infection and resistance : an exposition of the biological phenomena underlying the occurrence of infection and the recovery of the animal body from infectious disease, with a consideration of the principles underlying specific diagnosis and therapeutic measures / by Hans Zinsser.

  • Zinsser, Hans, 1878-1940.
Date:
1923
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Licence: In copyright

Credit: Infection and resistance : an exposition of the biological phenomena underlying the occurrence of infection and the recovery of the animal body from infectious disease, with a consideration of the principles underlying specific diagnosis and therapeutic measures / by Hans Zinsser. Source: Wellcome Collection.

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    Titration of antigen. Titration of haemolytic sensitizer. Alexin titra- tion. Performance of the text. Noguchi’s modification. Modifications of Bauer, Stern and others. Results of test. Reliability. Spinal fluid, etc. Direct precipitation methods in syphilis. Sachs-Goorgi re- action. Kahn reaction. Complement or Alexin Fixation for the De- termination of Unknown Protein. Xeisser Sachs method. Principles of the method. Performance of test. Complement Fixation Tests in Diagnosis of Malignant Neoplasms. Historical. Von Dungern’s method. Results obtained. Complement-fixation in glanders. Comple- ment-fixation in gonococcus infections. Complement-fixation in tuber- culosis. The preparation of bacterial antigens for complement fixation as advised by writer. Chapter IX.—Tiie Phenomenon of Agglutination Discovery. Applications of clinical methods. Clinical usefulness. Rela- tion of motility. Passive role of bacteria Bordet’s discovery of the importance of electrolytes. Nature of agglutinogen. Alterations by heat. Alterations in agglutinability. Reasons for agglutinability. Specificity. Biological relations between bacteria parallel to agglutinins. Castellani’s method of absorption. Normal agglutinins. Agglutinoids. Inhibition zones. Bordet’s views. “Two-phase” theory. Physical interpretation. The work of Neisser and Friedemann. Recent work of Northrop and deKruif. Acid agglutination. Iso-agglutinins. Func- tional importance of agglutination in infectious diseases. Chapter X.—The Phenomenon of Precipitation ..... (Precipitins) Discovery by Kraus. Extension to bacterial antigens. Conception of the precipitinogen. Chemical definition of precipitinogens. Specificity. Methods of producing precipitins in animals. Species specificity and zoological significance. Nuttall’s work. Forensic precipitin tests. Alteration of precipitinogen bv heat and other physical factors. Organ specificity. Ehrlich’s conception of the precipitins. Physical concep- tions and colloidal analogies. Rapid precipitin production. Simul- taneous presence of precipitinogen and precipitin in the same serum. Chapter XI.—Iso-antibodies Ehrlich and Morgenroth’s early work on iso-hemolysins. Similar work on other animal species. Iso-antibodies in human blood. Landsteiner’s early work. Classification of Jansky and of Moss. Hereditary charac- ter of blood grouping. Medical and biological importance. Chapter XII.—Further Consideration of the Nature of Antibodies General consideration of biology of antibody formations. Nature of substances which alter the control of cell reactions on successive ad- ministration. Basic function of tissue cell in this regard. The cell con- sidered as a chemical and physical unit. Suggestion of relationship be- tween antigenic function and non -diffusibility. The union of antigen with antibody. Purely chemical and physical ideas. Influence of Loeb’s recent work on these conceptions. Relationship of antigen-antibody union and hydrogen ion concentration. Influence of cells. Dissociation of antigen and antibodies. Landsteiner’s work. Recent development of this by Huntoon. On the essential identity of the antibody. General development of the writer’s idea concerning the identity of antibodies. Attempts at physical measurement of the antibody reaction. Bordet- Danysz phenomenon. The epiphanin reaction. The meiostagmin reac- tion. Colloidal gold reaction. PACK 240 272 297 306