On hereditary diabetes insipidus : with special regard to a sex-linked form / by Hans Forssman.

  • Forssman, Hans (Hans Axel), 1912-
Date:
1945
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: On hereditary diabetes insipidus : with special regard to a sex-linked form / by Hans Forssman. Source: Wellcome Collection.

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    ON HEREDITARY DIABETES INSIPIDUS 21 Cachin 1932). In the case described by Duvoir et al., there was a mitigation of the diabetes insipidus in each of 3 separate pregnancies, the complaint again becoming worse after partus. The case was comphcated with diabetes melhtus and great obesity. Quite a number of cases have been communicated where diabetes insipidus was first contracted in association with pregnancy. 27 cases of this kind have been collected from the literature in table 1. In 17 of these cases the phenomenon occurred at the very first pregnancy, in 3 cases it was first observed in the 2nd pregnancy, 2 cases in the 3rd, 2 cases in the 4th, and 4 cases not until the 5th. Of the women who had already had diabetes insipidus gravidarum once, 11 sub¬ sequently went through one or more pregnancies, making a total between them of 35. In 32 of these pregnancies (9 women) there was a recurrence of diabetes insipidus; only 3 (2 women) proceeded with no recurrence. Janzen (1899) has noted a tendency in the disease to recur with enhanced intensity in sub¬ sequent pregnancies. It is necessarily difficult to pin down the point in time when the pathological thirst becomes noticeable, as the complaint develops insidiously. The table shows that only a few of the women registered their increased thirst as early as the be¬ ginning of pregnancy; most of them noticed it in the middle, diiring the 4th to 6th months. Merlino (1938) describes how the symptoms manifested themselves weakly in the 2nd month, but grew in intensity from the 4th. The last weeks of pregnancy are usually the Avorst. In one case (Schellenberg 1930) the symptoms did not appear until the 9th month. Just as the intensified permanent diabetes insipidus of pregnancy returns to habitual proportions soon after partus, so does the diabetes insipidus gravidarum begin to disappear immediately partus is over — in Pribrsky's case (1934) as early as the beginning of labour; otherwise one of the first days of the puerperium. After one week the daily output of urine is often wholly normal. In other cases there is a rapid improvement, but a complete return to normal takes several weeks. In other cases, again, there is never any complete