Creatin and creatinin / by Edward Mellanby.

  • Mellanby, Edward, Sir, 1884-1955.
Date:
[1908?]
Catalogue details

Licence: In copyright

Credit: Creatin and creatinin / by Edward Mellanby. Source: Wellcome Collection.

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    [.Reprinted from the Journal of Physiology. Vol. XXXVI. Xo. 6, February 28, 1908,] CREATIN AND CREATININ. By EDWARD MELLANBY, B.A. Research Student of Emmanuel College, Cambridge. {From the Physiological Laboratory, Cambridge.) CONTENTS. 1. Historical .. 2. Method of estimation .......... 3. The stability of creatin in muscle ........ (a) The alleged presence of creatinin in muscle . (b) The influence of survival and the contraction of muscle on creatin ........... (c) The influence of autolysing tissues on creatin and creatinin . 4. The effect of glycocyamin feeding on the creatin in chickens’ muscle . 5. The effect of feeding with creatin and creatinin on the percentage of creatin in muscle .......... 6. The ontogeny and phylogeny of creatin ....... 7. The excretion of creatin and creatinin in pathological conditions 8. Have creatin and creatinin a function ? . . . . . ... 9. General conclusions .. PAGE 446 450 455 455 458 461 465 467 471 479 484 486 1. Historical. The chemical investigation of muscle was started by Liebig(1) in 1847 when he published work describing the effect of fatigue on muscle. He found that muscle work increased its contents of creatin so that those muscles which performed most work contained the most creatin. At this time he performed the classical experiment of the hunted fox, in muscles of which he found ten times the quantity of creatin present in the muscles of the resting animal. Since Liebig’s time many physiologists have worked on creatin in muscle and their results have been widely different. Sarokow*2 found that resting muscle contained twice as much creatin as creatinin and that the result of work was to increase the creatin and at the same time to change some of it to creatinin. It was stated by Sczelkow that tetanus produced an increase, rest a decrease of creatin in muscle,