Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists.

  • Knoll AG (Ludwigshafen am Rhein, Germany)
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists. Source: Wellcome Collection.

    21/24 (page 19)
    o be regarded as due to obstruction of the general circulation . e. where valvular insufficiency, etc., were present.” Dr. Th. K. Geissler (Clinic of Prof. Tschudnowsky, T Petersburg — Berl. klin. Wochenschrift 1891 No. 15—17) COuld Confirm he powerful diuretic action of Diuretin in all cases. Not only he quantity of urine, but also that of the solid constituents, ncreased considerably. The author, therefore, characterised )iuretin as a true and powerful diuretic. As regards he explanation of the result, he differs from other authors, n tracing it, not alone to a stimulation of the renal epi¬ thelium, but also, in part, to a strengthening of the heart’s action. He was able to demonstrate by means of the sphygmo¬ manometer , in all cases, an increase of arterial pressure (md a regulation of the pulse, and regards as a confirmation )f this view, the fact that, the most marked diuretic effects vere attained in valvular insufficiency, while, in myo-carditis, :he success was less conspicuous. The strengthening of the learts action, with a simultaneous stimulation of the secreting Dower of the renal epithelium, is a combination very favour- ible to diuresis. Dr. Kouindjy-Pomerantz who carried out experiments with Diuretin in the Hopital Cochin, Paris, under the direction jf Prof. Dujardin-Beaumetz sums up her conclusions as funder : “Diuretin is an excellent diuretic, more powerful than caffeine, in doses of 45—75 grns pro die; given in quantities of 15 grains every two or three hours; it directly influences the renal epithelium.” “No action on the heart could be observed. Diuretin brings about a rapid increase in the volume of urine and the diuresis lasts twice or three times as long as with caffeine. Habituation does not soon occur. Micturition is easy and does not cause burning in the urethra. The remedy has no action on the central nervous system. It is administered in milk or chocolate between meals. In cases of dropsy where diuresis was still possible the success was marked while it did not follow when the kidneys had undergone great changes. See also reports on Diuretin by u British Medical ‘Journal”y June 6. i8gi7 uMedical & Surgical Reporter”; May jo. i8yr, “ The Lancet”, October n. i8yo, uEdinburgh Medical Journal, December iScjo. ► t ^