Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists.

  • Knoll AG (Ludwigshafen am Rhein, Germany)
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists. Source: Wellcome Collection.

    19/24 (page 17)
    1) Diuretin is a powerful and true diuretic in that |; brings about simultaneously an increased excretion of the I queous and solid constituents of the urine. 2) Its action is due to a direct but non-irritating influence m the renal epithelium; it neither produces the appearance if albumen nor alters the proportion if already existent in the trine. The favourable effect upon the circulatory organs requently seen is most probably of secondary origin. 3) Diuretin produces its diuretic action best in acute and Tronic affections of the heart and kidneys, and in the first dace are the acute renal inflammations and pure cardiac valvular inefficiency. Chronic nephritis and affections of the :ardiac muscular system are also benefitted but in purely serous exudations, such as in the dropsical stage of tuberculosis, 10 success is to be expected from the treatment. 4) Diuretin can be administered continuously and in .arge doses (up to 2 drms pro die) without any dan¬ gerous effects and the diuretic action is not in the least snfeebled when the remedy is repeatedly given to one and the same patient.” To these recent communications, the following extracts from the works of previous authors of eminence may be added. Summing up a laborious treatise on the use of Diuretin, Dr. A. Hoffmann (Clinic of Prof. Erb, Heidelberg) says (Archiv f. experim. Pathol, and Pharm. Vol. 28 p. 1): “Diuretin is by virtue of the Theobromine it contains, a diuretic of excellent effect, which merits extended ap¬ plication in the treatment of general dropsy. In liquid exudations following on inflammation of the serous layers of the skin, it is of less and, in obstruction of the portal circulation, of no value. The diuretic action is dependent upon a direct influence of the renal epithelium; at the same time, a certain favourable effect upon the circulatory organs, cannot be overlooked. Given in the correct dose of D/4 drm -pro die and in the right form, it is without any disturbing bye-effects. General well-being was beneficially influenced. Diuretin exerts a diuretic effect under circumstances where other remedies of the same class, such as digitalis, strophan- thus, caffeine, etc., have failed. It has no cumulative action and the effect quickly ceases so soon as the remedy is dis-