The diagnosis and treatment of dementia praecox / by Bayard Holmes. Experience with nuclein in the treatment of insanity / by Franz Hauber. Nuclein in paralysis agitans.

  • Holmes, Bayard, 1852-1924.
Date:
1914
Catalogue details

Licence: In copyright

Credit: The diagnosis and treatment of dementia praecox / by Bayard Holmes. Experience with nuclein in the treatment of insanity / by Franz Hauber. Nuclein in paralysis agitans. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    and in paresis of the insane than will an ex- temporized normal-salt solution like that employed by Donath. The Lundvall solu- tion contains other substances stimulating leukocytosis besides the nuclein; the quassin, for instance—as Doctor Lundvall has in- formed us in a personal letter—being added for that purpose. So, also, the sodium cinnimate stimulates leukocytosis, although Lundvall has recently informed us that he is now discontinuing this substance and sub- stituting for it arsenous acid; which latter is powerfully tonic and thus adds to the recon- structive power of the other ingredients of the formula. We venture to hope that among those who may read this article by Hauber there may be some who will feel inclined to try out this method of treatment thoroughly: making a scientific study of the blood-picture in all cases, verifying the diagnosis by the Abder- halden and other appropriate tests, and keep- ing a close watch upon the diet, exercise, ex- posure to sun, condition of the alimentary canal, and the various other factors neces- sarily playing an important part in contribut- ing to improvement and eventual recovery. It is with the expectation that the publica- tion of these articles may stimulate investi- gations along this line in America that we have submitted them to the readers of our journal.—Ed. Nuclein in Paralysis Agitans Parkinson’s disease (paralysis agitans) is so resistant to treatment that any method of handling cases of this kind that promises benefit deserves study. Buia has recently quoted a series of cases of this disease in which nuclein was used. (See Compt. Rend, d. 1. Soc. d. Biol., 1914, p. 507.) Buia employs a 10-percent solution of sodium nucleinate in physiologic serum. He gave it by mouth, hypodermically, and also intravenously. When taken internally, no effects were observed. Administered sub- cutaneously, the maximum dose was 40 centigrams (6 grains); beginning, however, with a much smaller dose and then increasing by 5 centigrams every two days, until this maximum was reached. Five patients were treated in this way, and all of them were benefited. However, the best results were obtained when the remedy was given by the intrave- nous route, the same solution being employed. Sometimes the immediate response was slight; in others, there was a well-marked rise of temperature, with slight chill, while in a third there was observed some diminution of tremor, a lessening of the muscular rigidity and in the rise of temperature, the latter sub- siding to normal in about four hours, with some rise in the blood pressure. In the second class of patients, there was general improvement following the immediate symptoms produced by the injection of the nuclein. Continuance of this treatment was marked by definite psychic improvement, accompanied by lessening of tremor and in- crease in muscular force. This benefit ex- hibited some degree of permanency. No untoward symptoms developed, although in some instances nausea, vomiting, and vertigo developed when more than 35 or 40 centi- grams of the remedy was administered. There was occasional tachycardia, dyspnea, and headache. However, these depressing symptoms are not observed when the drug is given in moderate doses. We should like to see the Lundvall solution, ^containing nuclein, arsenic and quassine, tried thoroughly in some of these cases. It should prove of value. PRICES OF LUNDVALL’S SOLUTION Per box of six 10 Cc. ampules, in less than half-doz. box quantities. $4.00 Per doz. boxes $40.00 For supplies of the above, as well as all other listed items, send your orders to the nearest point named below. Your pharmacist should be in stock. Ask anyway. If he is not responsive, order direct. If you haven’t a copy of our complete 400-page therapeutic price list (1913-1914), with its over one- hundred pages of “tried-and-true” Clinical Suggestions, it is yours for the asking. THE ABBOTT ALKALOIDAL COMPANY ( THE ABBOTT LABORATORIES ) Home Office :: Ravenswood, CHICAGO SEATTLE SAN FRANCISCO LOS ANGELES NEW YORK TORONTO BOMBAY