Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberators / by W. Feldberg and W.D.M. Paton.

  • Feldberg, W. S.
Date:
[1951?]
Catalogue details

Licence: In copyright

Credit: Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberators / by W. Feldberg and W.D.M. Paton. Source: Wellcome Collection.

    10/20 (page 499)
    From the curve it is possible to say that, after the injection of a histamine liberator, two-thirds of the total output of histamine will be obtained when a volume of perfusate equal to 15-25 % of the muscle volume has been collected. This is independent of the extent of vasoconstriction, the size of the muscle. Volume of perfusate (as % muscle volume) (&) Fig. 5. Histamine output from perfused cat’s gastrocnemius muscles after the injection of hista¬ mine liberators. The numbers refer to the experiments of Table 3, and P refers to experiments with 5 mg. propamidine. The ordinates give the histamine output as percentage of total histamine released. In (a) the abscissae give time in minutes, in (b) volume of perfusate collected as percentage of muscle volume. Histamine liberators injected at 0. the dose of liberator, the nature of the liberator, or the amount of histamine released. Further, the course of release is a regular one of approximately exponential type such that equal fractions of the histamine remaining in the muscle are released into equal, successive volumes of perfusate. Fig. 6 shows the output of three representative experiments with different histamine liberators plotted in this way.