The chemistry of nerve-degeneration / by F.W. Mott and W.D. Halliburton.

  • Mott, F. W. (Frederick Walker), 1853-1926.
Date:
1901
Catalogue details

Licence: In copyright

Credit: The chemistry of nerve-degeneration / by F.W. Mott and W.D. Halliburton. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Cat K.—One sciatic nerve only divided. The animal was killed 24 hours later. The peripheral end of the cut nerve was stimulated mechanically and electrically, and well-marked muscidar contraction followed. The divided nerve was compared with the healthy nerve on the other side Iry means of faradisation, a Du Eois Eeymond coil with one cell being used. The weakest induction shock which produced a muscular response occurred with the secondary coil at 27 centims. on the healthy side and 2.3 in the case of the divided nerve. The divided nerve, on subsecpient examination, was found to Im lioth histologically and chemically normal. C(d ./.—Both nerves divided. This animal was killed 2 days and 5 hours after the operation. Left nerve ; muscles responded with the secondary coil at 20. Eight nerve: muscles responded with the secondary coil at 2-5. The muscles on each side responded readily to mechanical excitation of the nerves. The nerves were practically healthy Imth histologically and chemically. Cat B.—Both nerves divided. This atiimal was killed .3 days after the operation. Left sciatic ; muscles I'esponded with the secondary coil at 18. Eight sciatic : muscles responded with the secondary coil at 22. The response to mechanical stimulation was slight. The nerves on chemical and histological examination show but little sign of degeneration. Cat P.—Both nerves divided. This animal was killed 3 days 20 hours after the operation. There was no muscular response on stimulating either nerve. Signs of commencing degeneration are evident. Cat C.—Both nerves divided. This animal Avas killed 4 days 3 hours after the operation. No response occurred on either side to stimulation. Signs of early stages of Wallerian degenei'ation are seen. Cat E.—Both nerves divided. This animal was killed .3 days after the operation. In this animal no muscular response occurred on excitation of either nerve; and the same is true for the animals that were killed at later stages, until union and regeneration has taken place. Degenerative changes in the nerves are more marked. Cat D.—Both nerves divided. This animal Avas killed 6 days after operation. Degenerative changes in the nerves are about the same as in Cat E. Cat It.—Both nerves divided. This animal Avas killed 8 days after the operation. Cat N.—Both nerves divided. This animal Avas killed 10 days after the operation. Cat Q.—Both nerves divided. This animal Avas killed 13 days after the operation. In these three animals (E, N, Q) the degenerative change is extremely Avell seen by the Marchi method Cat J.—Both nerves divided. This animal Avas killed 25 days after the operation. Cat 0.—Both nerves divided. This animal Avas killed 27 days after the operation. Cat JV.—Both nerves divided. The left nerve was sutured Avith catgut. This animal was killed 29 days after the operation. In these three cats (J, 0, W) there was considerable Avasting of the muscles supplied by the sciatics. LTnion of the divided nerves had occurred in all cases, but they Avere all irresponsive to stimulation. Little or no differense could be detected histologically or chemically in the tAvo nerves of Cat W, one of Avhich had been sutured. The Marchi reaction Avas still Avell marked, but there Avas evidence that absorption of the fatty jn'oducts of degeneration Avas in progress. Phosphorised fat had almost, and in the case of Cat W entirely, disa2Jpeared. Cat H.—Both nerves divided. This animal Avas killed 44 days after the operation. Good union had occurred on I)oth sides, Imt the nerves were irresjjonsive to stimulation. Degeneration had noAv advanced so far that there Avas almost complete removal of the jnoducts of degeneration. There are early .signs of regeneration. Here also the Avasting of muscles Avas very evident. Cat T.—Both nerves divided; left sutured AAuth catgut. This animal was killed 45 days after the operation. In this animal, for the few days preceding its death, the paralysis was less marked on the sutured side.