On some non-specific reactions of mallein / by H.J. Südemersen and A.T. Glenny.

  • Südmersen, Henry J.
Date:
[1908?]
Catalogue details

Licence: Public Domain Mark

Credit: On some non-specific reactions of mallein / by H.J. Südemersen and A.T. Glenny. Source: Wellcome Collection.

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    against Staphylococcus) gave no reaction with mallein but responded to the injection of Staphylococcus products. The details of the results are given in Table IX. Diphtheria. Moderately weak diphtheria toxin was used in doses of 0 5 c.c. The only horses to react were those which had been immunised against diphtheria toxin, numbers 32, 36, and 48; in the case of number 32, no reaction was obtained with mallein. This result is particularly interesting in consideration of the fact that the dose of toxin used together with less than one five-hundredth of a c.c. of the serum from either 36 or 48 would cause no swelling in a guinea-pig. Both horses 10 and 37 which had reacted to mallein failed to react to diphtheria toxin. In no case was there any temperature reaction. The results are recorded in Table X. Proteus. Very marked reactions resulted from injecting horses 1 and 13 with 0 5 c.c. of the filtrate from a three months old growth of B. proteus on broth. The general results obtained differ considerably from the result of the mallein injection. Horse 8 (venom) gave a reaction while horses 2 (,Streptococcus) and 36 (diphtheria) failed to do so. It is interesting to note that proteus is the only bacterial product which has given a reaction on horse 8. A rise in temperature occurred in the case of horse 2 which received an injection of Streptococcus products at the same time as the proteus injection. The results are recorded in Table XI. Pyocyaneus. Table XII gives the results of injecting 0 2 c.c. of a three months old filtered broth culture of B. pyocyaneus. High temperatures were obtained with horse 7, injected at the same time with 1 c.c. of 2 5°/o phenol; this may be due to the considerable exercise which the horse endured shortly after injecting, and during the following day. Horses 2 {Streptococcus) and 47 (diphtheria) were the only animals to produce well-defined swellings. Well immunised animals such as 10, 20, 30, 31, all failed to react. Acidi Lactici. The filtrate from a three months’ growth on broth of B. acidi lactici was used in doses of 02 c.c. Table XIII shows that the results do not differ from those obtained after injecting mallein.