Observations and experiments on the pathology of Graves's disease / by Walter Edmunds.

  • Edmunds, Walter.
Date:
[1895]
Catalogue details

Licence: Public Domain Mark

Credit: Observations and experiments on the pathology of Graves's disease / by Walter Edmunds. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    Illustrating Mr. Walter Edmunds' Observations and Experi- ments on the Pathology of Graves's Disease. Fis. 1.—Section of accessory thyroid of rabbit. 102 days previous to the rabbit being killed, and tbis specimen obtained, the whole of the thyroid proper of the rabbit had been removed, leaving only the two parathyroids. These after death were found not to be much, if at all, hypertrophied, nor was their micro- scopic structure materially altered; no vesicles and no colloid were seen, (x 380.) Fig. 2.—The whole of one lobe, including the parathyroid and the greater part of the other lobe (excluding the parathyroid) of the thyroid of a dog was excbed. No symptoms followed, and at the end of nine days the dog was killed. The figure represents, highly magnified, the lining (secreting) mem- branes of two adjacent vesicles back to back. It will be noticed that the membranes are greatly hypertrophied, and that this is effected by the enlarge- ment of tlie cells rather than by their multiplication. Contrast with Mg. 4. Plate XIII, tig. 1, is from the same specimen as this figure. ( x 500.) Fig. 3.—Section of normal accessory thyroid of rabbit. It contains no vegicles and no colloid. The clear spaces are probably due to drops of secretion, bnt tbis does not stain in the same way that the colloid in the thyroid proper of the rabbit does. ( x 380.) Fie. 4.—Secretion of the thyroid of a cretin. It was obtained from the body of a girl aged ten, who was the subject of cretinism. The thyroid did not appear atrophied. The sections show little colloid in the vesicles, but there is a considerable multiplication of the secreting cells lining the vesicles. Contrast this with Fig. 2. It would seem that there is some antagonism between the multiplication of the cells and the performance of their secreting function. I am indebted to Mr. Bidwell for this specimen. ( x 250.) Pi6. 5.—Section of small nodule from the surface or vicinity of the normal thyroid of man. (The patient died of phthisis.) It will be noticed that there are no vesicles and no colloid, and that the structure consists mainly of columns of cells, thus resembling the structure of the embryonic thyroid, and also of the parathyroid as seen in various mammals. ( x 220.)