Angiotensin and hypertension in pregnancy.

Date:
1979
  • Videos

About this work

Description

A discussion between Dr. Fiona Broughton Pipkin, University of Nottingham, and Mr. Geoffrey Chamberlain. The following summary accompanies the cassette: "Angiotensin II (AII) is an extremely powerful vascoconstrictor hormone, formed by the action of the enzyme renin on an -d-globulin substrate. Levels of renin and AII are high inn normal pregnancy but a specific compensatory diminution in vascular reactivity probably via PGEs, protects against hypertension. In hypertensive pregnancy (PIH), this protection is lost, and levels of AII are usually still further increased. There is a positive statistical relationship between diastolic BP and AII levels in pregnancy in humans and sheep. The administration of an AII receptor blocker to conscious pregnant sheep evokes a dose-dependent fall in blood pressure, the size of which is proportional to initial AII levels. There is also increasing indirect evidence that the feto-placental unit may contribute to circulating ALL levels. It is suggested that the relative ischaemia of the feto-placental unit in PIH results in increased AII production, as in the ischaemic kidney. This then results in increased PGE production in the uterus, which, together with the increased systemic BP improves feto-placental perfusion. This PIH may initially be a physiological response on the part of the feto-placental unit."

Publication/Creation

London : University of London Audio-Visual Centre, 1979.

Physical description

1 videocassette (VHS) (30.28 min.) : sound, black and white, PAL.
1 videocassette (Umatic) (30.28 min.) : sound, black and white, PAL.
1 videocassette (1-inch) (30.28 min.) : sound, black and white, PAL.
1 videocassette (Digibeta) (30.28 min.) : sound, black and white, PAL.
1 DVD (30.28 min.) : sound, black and white, PAL.

Notes

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest.

Creator/production credits

Discussed by Mr Geoffrey Chamberlain and Dr Fiona Broughton-Pipkin, University of Nottingham. Medical editor: Mr Geoffrey Chamberlain. Produced by Jennie Smith. Lithograph courtesy of Henry Moore OM. Made by University of London Audio-Visual Centre. Made for Postgraduate Medical Federation in association with The Blair Bell Research Society.

Copyright note

University of London

Type/Technique

Languages

Where to find it

  • Location Access
    Closed stores
    3042UM

    Note

  • LocationStatusAccess
    Closed stores
    3042VM
  • LocationStatusAccess
    Closed stores
    3042D

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