The elements of a new materia medica and therapeutics : based upon an entirely new collection of drug-provings and clinical experience / by E.E. Marcy, J.C. Peters & Otto Füllgraff.

  • Marcy, E. E. (Erastus Edgerton), 1815-1900.
Date:
[1859-1861]
Catalogue details

Licence: Public Domain Mark

Credit: The elements of a new materia medica and therapeutics : based upon an entirely new collection of drug-provings and clinical experience / by E.E. Marcy, J.C. Peters & Otto Füllgraff. Source: Wellcome Collection.

Provider: This material has been provided by the National Library of Medicine (U.S.), through the Medical Heritage Library. The original may be consulted at the National Library of Medicine (U.S.)

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    flammation of the stomach; and, on inspection of it after death, traces of inflammation are found. In some instances of death by its out- ward application, the inflammation has been greater than where it hag been swallowed. Sproegel says, in a dog killed by its application to wounds, the whole stomach and intestines, outwardly and inwardly, were of a deep red color, blood was extravasated between the mem- branes, and clots found in the stomach. (9. 46.) Of the different preparations of Arsenic, those which are the most soluble are the most active. The metal itself is inert, in accordance with what appears to be a general law in toxicology. This state- ment, however, must be qualified in so far as this, that if the metal be given in a coarsely-powdered or pulverized state, a sufficient amount almost always becomes oxidized to give rise to symptoms of poison- ing. The most active preparations are probably the arseniuretted hydrogen, the black oxide, or fly-powder, and the white oxide. (9. 46.) The white oxide, however, is the most important, as with this we have most often to deal, and it is the power of this which it is desir- able to fix with some degree of precision. (9. 46.) It has been stated, by various systematic authors, that the white oxide will prove fatal to man in the dose of two grains. Hahnemann, according to Christison, says, in more special terms, that in circum- stances favorable to its action, four grains may cause death in twenty- four hours, and one or two grains in a few days. But neither he nor any of the other authors alluded to have mentioned actual cases. Fodere knew half a grain to cause colic and dysenteric flux, which continued obstinately for eight days; and Christison has related an instance where six persons, after taking each a grain in wine, during dinner, were seriously and violently affected for twelve hours. Mr. Alfred Taylor mentions three similar cases, occasioned by taking Ar- senic in port wine—one, an infant about sixteen months old, who got about one-third of a grain, a lady, who took a grain and a-half, and a gentleman, who got two grains and a-half—in all of which, violent vomiting and prostration, without pain, occurred for three or four hours, and the gentleman of the party did not recover for several days. M. Lachese mentions his having met with a number of cases of poison- ing from small doses in bread or soup, whence he concludes that even one-eighth of a grain, taken in food, may cause vomiting; that a quarter, or twice as much, taken once only, causes vomiting, colic and prostra- tion; that the same quantity, repeated the next day, renews these symptoms in such force as to render the individual unfit for work for several days, and that four such doses, taken at intervals during two days, that is between one and one-half and two grains in all, excite acute gastro-enteritis, and may prove fatal, since two individuals who had taken this much died—one in seven weeks, and the other three weeks later. The smallest fatal dose I (Christison) have found recorded elsewhere, is four grains and a half, and death ensued in six hours only; but the subject was a child four years old, and the poison was taken in solution. Alberti mentions the case of a man who died from