Experiments to determine the precise effect of bromide of potassium in epilepsy / by T. S. Clouston.

  • Clouston, T. S. (Thomas Smith), 1840-1915.
Date:
[1868]
Catalogue details

Licence: Public Domain Mark

Credit: Experiments to determine the precise effect of bromide of potassium in epilepsy / by T. S. Clouston. Source: Wellcome Collection.

Provider: This material has been provided by King’s College London. The original may be consulted at King’s College London.

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    every period of three weeks until forty grain doses were reached. In case any ill effect might result from this or larger doses, I continued to give forty grains for seven weeks, so that I might have time to observe the patients carefully. At the end of that time I gave them forty- five grain doses for three weeks, and then fifty grain doses for ten weeks longer. I then stopped the medicine in all the cases. During all this time (thirty-eight weeks) the number and kind of fits had been noted, the patients had been weighed, and their temperatures and pulses examined and noted every week, while they had been otherwise subjected to very careful observation as to their mental and bodily state. Effect of the medicine on the number of the fits.—I have put in a tabular form (see table I.), the results of my obser- vations in regard to the number of fits taken by the patients when they were not taking the medicine, and during each of the periods of three weeks when they were taking the different doses of the drug. TABLE I. Quantity taken per day. No. under treatment. Total No. of fits in three weeks. No. of fits to each patient in three weeks. No Medicine 29 398 13-5 15 grains 29 344 11-9 30 „ 29 269 93 45 „ 29 348 12 75 „ 29 174 6 90 „ 26* 61 23 105 „ 26 64 2-5 120 „ 26 86 3-4 135 „ 25 68 2-3 160 „ 20f 48 2*4 As various causes prevented me from continuing the experiments in the cases of all the patients on whom they were begun, I have given in one column the number of * One patient had taken acute rheumatism, one had turnod over in a fit and died, and in the third, a boy of 15, the medicine had to be Btopped. t Besides the above it had to be stopped in four more cases, on account of its 1 effects; in another boy I did not go on to the large doses; and in the ninth patient the delusion that it was poison I was giving him was so strong that I did not continue its use all the time.