Aniridia, Wilm's tumour, deletion - FISH

Human chromosomes highlighted by fluorescent probes which bind to specific sequences of DNA. This FISH (fluorescence in situ hybridisation) study is of a petient with a sub-microscopic deletion in chromosome 11 (11p13) which includes those tegions spanning the WAGR (Wilm's tumour, airidia, genital anomalies and mental retardation) region. The four chromosome sets shown have a green probe for the chromosome 11 centromere, and red probes for various parts of the WAGR, which are absent in one of the two chromosome 11s in each case. Image by Dr John Crolla.