On the modifications of the metabolism produced by the administration of diphtheria toxine / by D. Noel Paton ... [and others].

Date:
[1899]
Catalogue details

Licence: Public Domain Mark

Credit: On the modifications of the metabolism produced by the administration of diphtheria toxine / by D. Noel Paton ... [and others]. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    On June 6th 18*7 doses of diphtheria toxine (each lethal to 500 grm. guinea-pig) were injected subcutaneously. On June 7th the dog was ill and took no food. On June 8th the dog was better, but took only a little food1, and at 6 p.m. 125 immunisation units of antitoxine were injected. Temperature. Between May 30th and June 6th the temperature varied from 38A to 38-6° C. On the 7th it rose to 39*5° C. Next day it was 38*9° C. and after it fell to normal. Exp. IY. Nov. 19, 1898. An old pointer bitch weighing 24 kilos was put on a diet of Oatmeal 600 grm. Milk 500 c.c. Water 500 c.c. On the 27th (fifth day) no food was given. On the 30th about 11 doses of diphtheria toxine (each lethal for 500 grm. guinea-pig) were injected at 5’30. On Dec. 1st no food was taken. On Dec. 2 all the food was taken. Next day some of the food was left and the dog seemed ill. Temperature. From Nov. 26th to Nov. 30th the temperature varied between 37 '8 and 38'4° C. On Dec. 1st it rose to 38*8° C. but in the evening it was only 38-5° C. Weights. 4th day of exp. 20’9 kilos. 6th „ 20-7 >> 8 th „ 20*2 33 10 th „ 18-4 33 12 th ,, 20-2 33 1 Nitrogen of residue = 5-26 grms., so only 1‘58 grms. of Nitrogen were taken in food.