The composition of cinchona febrifuge / by J.A. Goodson and T.A. Henry.

  • Goodson, John Augustus.
Date:
[1930]
Catalogue details

Licence: Public Domain Mark

Credit: The composition of cinchona febrifuge / by J.A. Goodson and T.A. Henry. Source: Wellcome Collection.

    11/16 (page 245)
    “ Quinine Sulphate.”—These fractions from A yielded only 15*5 per cent., expressed on the precipitate, of ether-soluble base having [a] D —158° (c = 0*54 in alcohol). The quantity was too small for further examination and it was taken as quinine. The fraction from B yielded no quinine. In the case of C quinine and cin- chonidine were precipitated together as tartrate (see below). “ Ginchonidine Tartrate.”—This fraction from A yielded 78 per cent, of mixed bases, m.p. 155-160° and specific rotation [a] d —129*76° (c = 0*892 in alcohol), and which contained methoxyl 4*96 per cent. The methoxyl figure indicates the presence of quinine 52 and cinchonidine 48 per cent, in the mixed bases. These figures are very close to those found previously (p. 242). Such a mixture should have a specific rotation [a] D —136*4°. From the “cinchonidine tartrate” fraction from B neither quinine nor cinchonidine could be recovered. The mixed bases recovered from the cinchonidine tartrate of febrifuge C contained methoxyl 5*15 per cent, corresponding to quinine 53*7 and cinchonidine 46*3 per cent. A solution in alcohol after necessary decolorisation with charcoal had [a] d2 — 123*3° (c = 1*798 in alcohol). A mixture of the composition indicated by the methoxyl determination should have [a] D — 136*2°. “ Quinidine Hydriodide.—These fractions were examined as hydriodides and gave the following results: — Melting Point. Methoxyl Per Cent. [a]? in N-sulphurio Acid. A • • • • • • 269-270° 62 + 218’8° 13 ••• • • • 269-270° 62 -f 220'6° n yj • • • • • • 269-270° 62 + 218-5° Quinidine hydriodide melts at 269°, yields methoxyl 6*86 per cent, and has [a] D + 228*3° (c = 1*54 per cent in N/HaSCh). Quinidine base recovered from the A and B fractions had m.p. 168-9°; 168-9° and [a]D+ 246*3° (c = 0*776 in alcohol) and + 249*7° (c = 0*794 in alcohol). Babe’s12 figures are m.p. 172-3 and [a] D + 243*6°. It is clear that Chick’s process yields practically pure quinidine hydriodide. “ Cinchonine.”—The crude cinchonine isolated from the three febrifuges had the following characters :— Melting Point. [•]» Methoxyl, Per Cent. A 212° + 101-5° 272 B 190° + 1160° 435 C 230° + 182 4° 192