Contributions to the experimental pathology of spirillum fever / by H. Vandyke Carter ; (communicated by James Andrew).

  • Carter, H. V. (Henry Vandyke), 1831-1897.
Date:
1880
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the experimental pathology of spirillum fever / by H. Vandyke Carter ; (communicated by James Andrew). Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    was irregular. Experiment No. 4 is a good example. I need only add that this event furnishes evidence of a similarity, descending even to incidental characters, be- tween the human and comparative attacks of spirillum fever. Relapses.—The only two known instances have been described in Experiments 13 and 17; they resembled in all features ordinary mild attacks and occurred six and twelve days after the primary event. The extreme range in man was 5 and 12 days in an infinitely larger series than the present, and the average interval was practically invariable, hence my hesitation to insist upon this limited and irregular comparative experience. The absence of a relapse would be no argument against the identity of the spirillum fever of the monkey with the relapsing fever of man, for in the human subject second attacks are wanting in one fourth of cases, or even oftener, and still the invasion preserves its usual characters. I am not aware that relapses were overlooked in these experi- ments. The Post-mortem appearances in Spirillum-Fever. Twelve autopsies were made of nine animals killed at various stages, and in three dying of fever. During the in- cubation-period (three cases) commonly no striking change was noticed, but once deep congestion of the mucous membrane of the stomach, with minute petechias, about the middle of the viscus; liver and spleen congested. In five deaths during fever, vascularity of the stomach about the middle, with small petechias, and vascularity of the duodenum and the lower end of the ileum, with congestion of liver and spleen. In one animal bled to death the liver was almost translucent and the spleen small, flabby, and pale, which shows how little the solid parts were altered. Twice, however, there was pulmonary apoplexy ; the brain,