Contributions to the experimental pathology of spirillum fever / by H. Vandyke Carter ; (communicated by James Andrew).

  • Carter, H. V. (Henry Vandyke), 1831-1897.
Date:
1880
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the experimental pathology of spirillum fever / by H. Vandyke Carter ; (communicated by James Andrew). Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Stage of manifested Fever. Beginning.—Fever sets in from to 5 days (at most) after inoculation, the mean period being 75 to 80 hours, after excluding an exceptional instance. The hour is commonly near noon or somewhat later, but there is no rule, and it may be at night or early morning; since the majority of inoculations were practised at 5 p.m., no relationship of time here appears. A high temperature is attained on the first day, and generally within a very few hours (3 to 6), it may possibly be earlier, and is sometimes later (8 to 12 hours) ; this abrupt beginning of high fever is also a character of the attacks in man. The mean temperature at observed initiation was 104,8° for a morning rise, and 105° for an evening rise, botli figures being doubtless within the actual, yet sufficient to show how decided is the onset of fever. As the normal temperature of the monkey is higher than that of man by 3°, the absolute initial rise is not so great as in him, yet the upward limit being nearly the same on this first day it is observable that the spirillar pyrexia again displays its special character. Course.—As to duration, the induced fever is briefer than that of man, never lasting longer than 3* days (86 hours), in the mean barely 2 days (43 hours), and at the shortest only 6 hours. Such very varied duration has no counterpart in the first attack- of man, but it accords with the varying length of “ relapses ” in the human subject; so that the single comparative attack may be said to represent almost all known degrees of fever. Propor- tionately to its bulk of body the lower animal suffers more than equally, and so does the human infant, hence the hypothesis of a limited onateries morbi insitcc has no application here. One half the attacks might bo called mild, the fever lasting not more than 24—30 hours; the