Contributions to the experimental pathology of spirillum fever / by H. Vandyke Carter ; (communicated by James Andrew).

  • Carter, H. V. (Henry Vandyke), 1831-1897.
Date:
1880
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the experimental pathology of spirillum fever / by H. Vandyke Carter ; (communicated by James Andrew). Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    negative results. In the course of these experiments similar accidents to these little animals were not unusual. The above was my first essay, date February 26th, 1879, specimens of the infected blood were forwarded to Professor F. Cohn, and their character verified. Sixth experivient.—I. S. B., a lad of 14, whose father had relapsing fever, was not admitted until the first apyretic interval, but in a specimen of dried blood taken from him at their home I found the parasite in abundance. His relapse was much shorter than his father’s, and though the blood spirillum was at first very plentiful, his illness seemed to be of the mildest. On the morning of the second day (temp. 102,6°) the liquor sanguinis was clouded and contained some large protoplasmic bodies, and there were numerous active organisms to be seen. Ten minims of the defibrinated blood were injected hypodermically in each of the following monkeys at 10 a.m. 10th July. 2. Chain, a fresh animal brought to hospital the previous night, small and wild, had normal temperature and blood. The temperature took a normal course and was rather below the mean for the first three days, it then declined and rose into a mild paroxysm prior to the onset of high fever on the fifth day; the blood was ex- amined only twice daily, and forty-eight hours after inoculation a few active spirilla were found in the very clear plasma; next day there were more, and at last the blood was filled with the parasite. The animal was then ill, though still active, and it was killed for patho- logical inquiry. In this case high fever was preceded by a minor or quasi-abortive rise. 3. Rope, a similar subject and similarly treated, showed healthy blood and a temperature which, pursuing a normal course, was somewhat more pronounced than usual, until the advent of the blood parasite, forty-eight hours after inoculation. Death was then inflicted for the purpose of research at this commencement of specific infection. All charts are appended. The concordance of date upon which the spirillum was