An annotated catalogue of the mutant genes of the house mouse / H. Grüneberg.

  • Grüneberg, H. (Hans)
Date:
1956
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: An annotated catalogue of the mutant genes of the house mouse / H. Grüneberg. Source: Wellcome Collection.

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    24 MUTANT GENES OF THE HOUSE MOUSE single 'main' gene. It occurs frequently in a highly inbred strain of mice ('A' strain). The genetics of a type of median harelip (with a cleft separating the incisors) is not completely known ; the entity is now extinct. 110. Hydrops The 'hydrops' of mice (Hertwig, 1955) traces back to a male whose sire had been subjected to X-ray treatment. In this strain, various types of anomaly are encountered. These include embryos with pseudencephaly, hydropic animals which die soon after birth, and various other lethal types which die in the first few weeks ; the latter include one group of young with a characteristic stilt-like gait and degenerative processes in the flocculus cerebelli. It has been suggested that the anomalies found in this stock are the result of a reciprocal translocation between two chromosomes. On this interpretation, the various anomalies, at least in part, represent different unbalanced genotypes; they are not, as in many of the other conditions described in this catalogue, variable expressions of the same gene mutation.