Histamine receptors and peptic ulcer disease.

London : University of London Audio-Visual Centre, 1976.

1 encoded moving image (37.17 min.) : sound, black and white.

00:37:17

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

InEnglish

Presetned by Professor J Black FRS, Deparemtne of Pharmacology, University College London and Professor J Wyllie FRCS, University College Hospital Medical School. produced by Martin Hayden. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Professor Black introduces the lecture. He gives a brief history of the discovery of histamine H2-receptor antagonist medications and shows a table detailing the properties of antihistamine drugs. He shows a further table detailing the patterns of different hormone responses to various antihistamine medications. Time start: 00:00:00:00 Time end: 00:05:43:00 Length: 00:05:43:00

Segment 2 Black continues to refer to the table listing different hormonal responses to antihistamine medications. He runs through the properties and effects of each drug in detail. He then shows an illustration of the chemical properties of various antihistamines. Time start: 00:05:43:00 Time end: 00:10:40:00 Length: 00:05:57:00

Segment 3 Black continues to compare antihistamine medications. He plots their effectiveness on a graph which takes into account dose ratio and response. Time start: 00:10:40:00 Time end: 00:17:06:00 Length: 00:06:26:00

Segment 4 Black refers to graphs and tables charting dose ratio to response statistics of different antihistamine agents. He gives examples of various pharmacological studies on each of the drugs. He hands over to White. Time start: 00:17:06:00 Time end: 00:21:09:00 Length: 00:04:03:00

Segment 5 Black shows a table listing all known histamine receptors then hands over to Whyllie. Whyllie discusses the particular relationship between histamine suppressing drugs and gastric secretion. He shows a graph detailing histamine-stimulated gastric secretion in man. He then shows a further graph detailing he suppression of gastric secretion in man by antihistamine agents. Time start: 00:21:09:00 Time end: 00:28:29:00 Length: 00:07:20:00

Segment 6 Wyllie discusses the effects of antihistamine medications on the vagus nerve. he then describes the results of a test of the drug metiamide to treat duodenal ulcer; he refers to a graph which shows the rates of ulcer healing due to this medication. After that, Wyllie shows the same tables but this time relating to cemitidine. He concludes by saying that, of the two, cemitidine is probably the more effective for future development. Time start: 00:28:29:00 Time end: 00:37:17:15 Length: 00:09:12:15