The constituents of cluytia similis / by Frank Tutin and Hubert W.B. Clewer.

  • Tutin, Frank.
Date:
[1912?]
Catalogue details

Licence: Public Domain Mark

Credit: The constituents of cluytia similis / by Frank Tutin and Hubert W.B. Clewer. Source: Wellcome Collection.

    13/18 (page 2231)
    however, a red liquid was obtained, which, when acidified, yielded a yellow powder, ihe latter was collected, when it was found to be almost insoluble in alcohol or ethyl acetate, but crystallised from dilute pyridine in small rosettes of brownish-red needles, which decomposed and melted at 315°. This substance dissolved in con¬ centrated sulphuric acid with a crimson colour, and possessed the propeities of a phenolic anthraqumone derivative: 0*0904 gave 0-2134 C02 and 0*0331 H90. 0=64*4- H = 4*l 0*0957 „ 0*2265 C02 „ 0*0352 H20. C = 64*5 ; H = 4*l.‘ Ci4nio°5 requires C = 65*l; H = 3*9 per cent. After each of these combustions a small amount (about 0*0005 gram) of inorganic residue was left in the boat, which would account for the somewhat low percentage of carbon found. The only known compound with which the above-described anthraqumone derivative could be identical is a substance described by Tschirch (Arch. Pharm., 1900, 238, 427), but as this author does not record the melting point of the anthraquinone derivative he obtained it is impossible to say whether the latter is identical with the substance here described. The substance obtained from Gluytia similis, which is probably a trihydroxydihydroanthraquinone, yielded an acetyl derivative, which crystallised in small, yellow needles, melting at 167°. The neutral portion of the ethereal extract of the resin from which the above-described substance had been separated, consisted only of amorphous products Chloroform, Ethyl Acetate, and Alcohol Extracts of the Resin. The chloroform extract of the resin was dark green, and amounted to 10 grams. It was thoroughly examined, and was found to consist of amorphous products, together with a small amount of the above-described substance, C14H10O5. Ihe ethyl acetate extract of the resin amounted to 7 grams, and consisted only of amorphous products. The alcohol extract of the resin amounted to 72 grams, and was a nearly black powder. It was submitted to both acid and alkaline hydrolysis, but nothing definite could be isolated from it. II.—Examination of the Root. A portion (10 grams) of the ground root of Gluytia similis was subjected to a preliminary test for an alkaloid by digestion with 1 rollius s fluid, but with a negative result. Another portion (25 grams) of the ground material was succes-