Cutaneous allergy in gonococcal infections ... / by Ernest Edward Irons.

  • Irons, Ernest E. (Ernest Edward), 1877-
Date:
1912
Catalogue details

Licence: Public Domain Mark

Credit: Cutaneous allergy in gonococcal infections ... / by Ernest Edward Irons. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    days. In all. the reaction in the first week was negative (i.e., there was no more reaction than occurs in normal individuals). In the second and third weeks, the papules became slightly larger, and by the l\)urlh week pronounced papules with surrounding hyperemia were noted. In epididymitis accompanying gonorrhea, the reaction varied in the cases studied. In several, tested on the third or fourth day of the epidid>'mitis, cutaneous reaction was pronounced. In Apr Way | 18 19 20 £1 22 23 24 25 26 27 28 29 10 1 2 3 4- 5 6 7 & 9 lO M iZ 13 14 13 16 17 10 ? f. 9 y £ 0^ ' a ^ c h T 7 i ^ ? A i S ■6 6 s / \ ?, f\ 1 i , 5 E ^. f V \ A ri j| A A / \ V ^ ^ J J /\ v/ \ r V J V t 1 V 1 / / 3 r* ,/ V \ J V V V f 2 V 1 Chart i.—Cutaneous allergy with respect to gonococcal extracts in a man 20 years old; first attack of gonorrhea in September, 1910; recurrence in August, 1911; arthritis in October, 1911; no discharge at present; now suffers from tender heels and ankles, and recurrent hydrops of right wrist with 7 days' cycle. Injections of killed gonococci as shown on the chart. two cases the reaction was faint on the second and third days, but by the fifth day, when the patient had begun to mend, the reaction became more definite. In arthritis, the degree of the reaction varied greatly. In several cases of extensive arthritis, the reaction was negative or slight. Later, when improvement in general condition occurred, the cutane- ous reaction became pronounced. In one case of extensive arthri- tis, in which improvement did not occur while under observation, a positive reaction was not obtained. In infected individuals giving a weak cutaneous reaction, the reaction may become positive on a second test after the inoculation of gonococcus vaccine (Chart i^. ' The curves shown in these charts were constructed from successivi determinations of the degree of cutaneous reaction following the inoculation of glycerin extracts of bacterial antigens. The degree of reaction was determined by recording the diameter in millimeters of the reactions obtained 24 hours after jnocuktion. In the gonococcal curves, each determination represents the average diameter of three simultaneous tests. The meningococcal curves were plotted from single determinations. Care was taken to make the inoculation? as nearly as possible uniform in depth, and in the amount of antigen inoculated . The reactions obtained from day to day were measured, and the data recorded on slips of paper without