On the relation of uric acid excretion to diet / by F. Gowland Hopkins and W.B. Hope.

  • Hopkins, Frederick Gowland, Sir, 1861-1947.
Date:
[1898?]
Catalogue details

Licence: Public Domain Mark

Credit: On the relation of uric acid excretion to diet / by F. Gowland Hopkins and W.B. Hope. Source: Wellcome Collection.

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    of the latter is at this early period (2nd to 5th hour) much greater, so that the ratio it bears to the urea is markedly raised; whereas later (5th to 10th hour), while the urea is still maintained above the level of the abstinence period, the uric acid falls to its abstinence value or even below this. A curve of the uric acid values expressed as fractions of the urea values (ratio curve) shows therefore, in general, a sharp rise soon after the meal, but during the later hours of digestion it drops below the level found before the meal. Exp. I. (F. H. April 24, 1896.) Abstained from 7 p.m. April 23. At 1 p.m. April 24, took 250 grms. beef (weighed raw) with 100 grms. bread. Hour Quantity of urine in c.c. Urea in grms. Uric acid in milligrms. Ratio uric acid: urea 10—11 a.m. 60 0-91 23 1 : 40 11—12 48 0-78 25 1 : 31 12— 1 p.m. 55 0-81 22 1 : 37 1— 2 55 0-70 30 1 : 23 2— 3 48 0-88 42 1 : 21 3— 4 85 0-91 52 1 : 18 4— 5 54 1*25 40 1 : 31 . 5— 6 58 1-78 44 1 : 40 6— 7 60 1-56 38 1 : 41 7— 8 49 1-05 29 1 : 36 8— 9 51 M0 24 1 : 46 9—10 45 1-42 24 1 : 59 10—11 36 0-98 20 1 : 49 11—12 38 0-98 16 1 : 61 11 12 1 2 3 4 6 6 7 8 9 10 11 12 Fig. 1. Curves of Urea and Uric Acid1. Exp. I. 1 In this curve and in those which follow the continuous line represents Uric Acid and the dotted line Urea. The uric acid curve represents its values in milligrammes ; that of