Manual of serum diagnosis / by Dr. O. Rostoski ; authorized translation by Dr. Charles Bolduan.

  • Rostoski, Otto.
Date:
1904
Catalogue details

Licence: In copyright

Credit: Manual of serum diagnosis / by Dr. O. Rostoski ; authorized translation by Dr. Charles Bolduan. Source: Wellcome Collection.

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    on ice until the following day to allow the serum to separate, or separation is effected by means of the centrifuge. The dilution is again effected by means of the mixing-pipette or of a uniform capillary tube on which marks have been made with the aid of a centimeter measure. The pipette of a Gower’s haemoglobinometer is also very useful for this pur- pose (Stern). So far as the clinical value of the Gruber-Widal reaction is concerned, the following points are im- portant: How early the reaction appears, whether it is found only in typhoid, and finally whether it is found in every case of typhoid or is occasionally absent. When the Reaction Appears.—An early appearance of the reaction would be especially important. It is just in the beginning of the disease that the diagnosis is often extremely difficult, because as a rule the classical symptoms gradually develop only in the course of the second week. The re- action is first observed on the fourth to the seventh day of the disease. A still earlier appearance is to be regarded as a great rarity, though such cases have been reported. Thus C. Fraenkel, John- ston and Taggart even report a positive reaction on the second day of the disease, and F. Pick and Kohler one on the third day.‘ Levy, out of thir- ^ Compare Kohler, Klinisches Jahrbuch 1902, pp. 52 and 53.