Ergotoxine and some other constituents of ergot / by George Barger and H.H. Dale.

  • Barger, George, 1878-1939.
Date:
[1907]
Catalogue details

Licence: In copyright

Credit: Ergotoxine and some other constituents of ergot / by George Barger and H.H. Dale. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    animal with destroyed brain, and under artificial respiration. In a cat under these conditions, 0*5 mgm. of a pure ergotoxine salt per kilo caused the characteristic marked rise of blood-pressure, succeeded by 4 vaso-motor reversal.’ Some variation occurred with different animals, but the dose necessary to reverse the vaso-motor effect of o*i mgm. of the suprarenal principle in the cat did not, in any case, differ widely from this. Rather more—about 1 mgm. per kilo.—was needed to reverse the motor effect of suprarenal or other sympathetic stimula- tion on the uterus of the cat in early pregnancy : in a case of later pregnancy the dose needed was larger. As with the impure prepara- tions, the sympathetic effects on the heart and the dilator of the iris were comparatively resistant to the paralysis. No quantitative determinations were made with other animals, but, in addition to the species previously examined with the impure preparations (cat, dog, rabbit, ferret, monkey and fowl), observations were made on the pig and the goat. Fig. 2 Cock, 2 kilos. Brain pithed. Artificial respiration. Carotid blood-pressure. Injections intravenous. At A—5 mgms. of ergotoxine in dilute caustic soda. At B—5 mgms. of ergotoxine in dilute caustic soda. At C—o’Oj mgms. of the suprarenal active principle. Note that even io mgms. have not obliterated or reversed the suprarenal effect.