Leptospiral jaundice in dogs (yellows) / by C,C, Okell, T. Dalling, and L.P. Pugh.

  • Okell, C. C. (Charles Cyril), 1888-1939.
Date:
1925
Catalogue details

Licence: In copyright

Credit: Leptospiral jaundice in dogs (yellows) / by C,C, Okell, T. Dalling, and L.P. Pugh. Source: Wellcome Collection.

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    lated intraperitoneally with 3 c.c. ground-up liver Dog 6, October 9, 1924. This pup did not develop clinical symptoms of disease, and when destroyed on October 31, 1924, was apparently healthy. The post-mortem examination showed no evidence of disease. Exp. Dog 13.—(Passage Dog 8 direct to Exp. Dog 13). Inocu¬ lated 2 c.c. mixture of ground-up organs of Dog 8 intraperitoneally October 29, 1924. Pup remained healthy till November 4, 1924, when it refused food, developed a thin watery discharge from nose and eyes, and suffered from diarrhoea with blood in the motions. Its temperature fell from 100 *8° F. to 95 -2° F. in twenty-four hours. No jaundice was evident. Death occurred on October 5, 1924. Post-mortem.—No jaundice. Liver congested. Gall-bladder full of dark bile. The whole intestine markedly inflamed. Two intus¬ susceptions were present. Mesenteric, sublumbar, and bronchial lymphatic glands enlarged and congested. Lungs showed six small fresh haemorrhagic spots and four larger discrete similar areas near their borders. No leptospirae were found. Guinea-pigs were not inoculated. Exp. Dog 17.—(Passage Dog 9 through guinea-pig to Exp. Dog 17). Inoculated 0 -25 c.c. ground-up guinea-pig liver intraperitoneally October 31, 1924. This pup appeared perfectly healthy till the evening of November 14, 1924, when its temperature was 102 -6° F., and a thin discharge was observed from its nose and eyes. Food was refused. On November 15, 1924, marked jaundice developed, and the temperature was 100 -2° F. The pup was killed. Post-mortem.—Jaundice intense and general. Lungs typical. A sero-fibrinous exudate was present in the mediastinum. Liver con¬ gested and gall-bladder full. There were areas of congestion on stomach and intestines. No intussusceptions were present. Mes¬ enteric lymphatic glands much enlarged and haemorrhagic. Lepto¬ spirae seen in the blood and ground-up liver. Guinea-pigs inoculated intraperitoneally with blood and with ground-up liver died from a typical leptospiral infection, and leptospirae were found in their various organs. Exp. Dog 18.—(Passage Dog 9 through guinea-pig to Exp. Dog 18). Inoculation, history, post-mortem, and results identical with those of Exp. Dog 17. Dogs experimentally infected with Leptospira of Rat Origin. Exp. Dog 1.—Inoculated intraperitoneally with 1 c.c. of ground-up liver from a guinea-pig dead of leptospira infection (Rat 2 leptospira) September 18, 1924.