Methodology in medical genetics : an introduction to statistical methods / Alan E.H. Emery.

  • Emery, Alan E. H.
Date:
1986
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Methodology in medical genetics : an introduction to statistical methods / Alan E.H. Emery. Source: Wellcome Collection.

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    Contents 1. Introduction 1 2. Hardy-Weínberg equilibrium and the estimation of gene frequencies 3 Hardy-Weinberg equilibrium 3 Estimation of autosomal gene frequencies 4 Determination of the expected frequencies of various matings and the phenotypes of their offspring 8 Estimation of multiple allele frequencies 10 3. Estimation of factors affecting the genetic structure of populations 12 Genetic drift 12 Assortative mating 15 Inbreeding 17 Gene flow 23 Selection 25 Mutation 33 Genetic distance 35 4. Segregation analysis 37 Complete ( = truncate) ascertainment 40 Single incomplete ascertainment 46 Multiple incomplete ascertainment 51 X-linked inheritance 53 5. Multifactorial inheritance 55 Tests for multifactorial inheritance 55 Estimation of heritability from family studies 57 Calculation of heritability 59 Estimation of heritability from twin studies 64 6. Genetic linkage 67 Autosomal linkage 67 Prior probabilities of linkage 73 Probability of linkage 73 Probability limits 73 Recombination fraction and map distance 74 X-linkage 75