Mammalian chimaeras / Anne McLaren.

  • McLaren, Anne.
Date:
[1976]
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Mammalian chimaeras / Anne McLaren. Source: Wellcome Collection.

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    76 Immunology and blood 100 -I 80 - _ 60 H u. 40 - 20 - 0 -• >\n \ \V ^1:1: ч\\ II >N\ C3H He ^ (C3H X CBA-T6) Fi Id \^- •W;, NVl K\\1 C57BL ► (C57BLX CBA-T6) F, {b) 60 - г 40 - 20 Ч 0 т: Fv 1 F Bone A marrow ^ V (CBA-T6xPDE) F,— PDF Spleen Thymus Peyer's patches Lymph nodes Fig. 28. The percentage of Fi cells in various lymphomyeloid tissues of seven chimaeric mice, (a) data from Gornish, Webster & Wegmann (1972); {b) data from Ford, Evans & Gardner (1975Ò). patterns that emerge are by no means uniform. Gornish, Webster & Weg¬ mann (1972) examined mitotic cells in bone marrow, spleen and thymus from five aggregation chimaeras between either C57BL and (C57BL x CBA-T6)Fi or C3H/He and (C3H x CBA-T6)Fi embryos, and found a striking con¬ cordance between the proportions of cells carrying the T6 chromosome in the various tissues of a given animal. Their results, illustrated in Fig. 2S{a), have been taken as support for the view that lymphomyeloid tissue throughout the body arises from a single stem-cell pool. On the other hand, two injection chimaeras of the (CBA-T6 x PDE)Fi^ PDE combination, subjected to extensive chromosomal analysis by Ford et al. {\975b), gave results which suggested that bone marrow, thymus and