Cardiac fibrosis as a result of coronary obstruction / by G. A. Gibson and Robert Muir.

  • Muir Robert, Sir, 1864-1959.
Date:
1894
Catalogue details

Licence: Public Domain Mark

Credit: Cardiac fibrosis as a result of coronary obstruction / by G. A. Gibson and Robert Muir. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    we have not been able to find any description of an extensive fibroid change of the same character as in this case. The most reasonable explanation of the fibroid condition is, that the impaired nutrition due to the small supply of blood produces gradual degenerative changes, which excite or are followed by interstitial overgrowth. We have already pointed out that the area of greatest change corresponded with the distribution of the anterior division of the left coronary artery, and that there was no sufficient disease in the latter or its branches to account for it. It may be that the results were more marked in this position, because the slight anastomosis with the right coronary artery assisted the posterior part of the ventricle more than the anterior. Of course the interstitial change might possibly have preceded and been independent of the stenosis of the artery, but there is no evidence of this being the case. The marked thinning of the wall of the left ventricle in front, without any aneurismal dilatation, is also worthy of note; and the case well illustrates one mode in which a lesion in the aorta may affect the left ventricle, and produce mitral incom- petence with its accompaniments. Literature. The following list contains a number of papers bearing on this subject:— Dickinson, 'Trans. Path. Soc. 1866, p. 53 ; Greenhow, ibid. 1867, p. 80; Greenfield, ibid. 1877, p. 157; S. West, ibid. 1883, p. 66; Samuelson, Virchow's Archiv, Bd. lxxxvi. s. 539; Percy Kidd, Trans. Path. Soc. 1886, p. 197; Sainsbury, ibid. 1887, p. 117 (Cases of Stenosis of Coronary Arteries); Weigert, “Die pathologische Gerinnungsvorgange, Virchow's Archiv, Bd. lxxix. s. 106; Iluber, “Ueber den Einfiuss der Kranzarterienerkrankungen auf das Herz, ibid. Bd. lxxxix. s. 236; Ziegler, “ Ueber Myomalacia Cordis,” ibid. Bd. xc. s. 211 ; Leyden, “Ueber die Sclerose der Coronar-Arterien, Zeitsch, f. Min. Mad. 1884, ss. 459, 539; Lindsay Steven, “On Fibroid Myocarditis,” Lectures in Lancet, 1887, ii., Journ. of Path. 1893, vol. ii. p. 190; Budor, “ Obliteration des artferes cardiaques,” Paris, 1888; Nicolle, “Les grandes sclciroses cardiaques,” Paris,