Intestinal auto-intoxication / by A. Combe. Together with an appendix on the lactic ferments with particular reference to their application in intestinal therapeutics / by Albert Fournier ; only authorized English adaptation by William Gaynor States.

  • Combe, A. (Adolphe), 1859-1916.
Date:
[1908]
Catalogue details

Licence: In copyright

Credit: Intestinal auto-intoxication / by A. Combe. Together with an appendix on the lactic ferments with particular reference to their application in intestinal therapeutics / by Albert Fournier ; only authorized English adaptation by William Gaynor States. Source: Wellcome Collection.

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    and these substances are formed in excess in the blood, we find présent the uric acid diathesis of arthritism. The same state of the blood may be found in leukæmia and pseudo leukæmia, owing to the abundant destruction of the nuclei of the leucocytes. This first group constitutes the nucleo- lytic auto-intoxications. Whenever the albumin, and especially the fats of the body are destroyed in too great quantities or too rapidly, fatty volatile acids are formed and also large quantities of ammonia, which these acids take from the albumin to saturate themselves with. When the fats are especially attacked, acetone is likewise pro- duced. This form of intoxication is sometimes called acid intoxica- tion, sometimes acetonæmia. It accompanies and is charac- teristic of starvation, insufficient food, carcinomatous cachexia, certain grave anæmias, many intestinal affections, but especially grave diabètes; in other words, it may be observed whenever the fats and albumins of the body are destroyed in exaggerated proportions. This second group constitutes the proteo and lypolyptic auto- intoxications. Forced marches, physical overexertion produce an undue quantity of sarcolactic acid, which cannot be eliminated as fast as formed; its accumulation brings on fatigue; should it be- come chronic there results an intoxication of which physical weariness or exhaustion is the symptomatic picture. The same probably holds good for nervous exhaustion. Such are the histogenic auto-intoxications; they hâve nothing to do with our spécial subject. B. ORGANOPATHIC AUTO-INTOXICATIONS The organopathic auto-intoxications are very numerous and vary greatly. A first group of glands is intended for the élimination of substances noxious to the organism. These are the glands of cxternal sécrétion. Whenever one of these glands becomes insufficient, there occurs a rétention in the body, of toxic substances which may