Animal models of inherited metabolic diseases : proceedings of the International Symposium on Animal Models of Inherited Metabolic Disease held in Bethesda, Maryland, October 19-20, 1981 / editors: Robert J. Desnick, Donald F. Patterson, Dante G. Scarpelli.

  • International Symposium on Animal Models of Inherited Metabolic Disease (1981 : Bethesda, Md.)
Date:
[1982], ©1982
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Credit: Animal models of inherited metabolic diseases : proceedings of the International Symposium on Animal Models of Inherited Metabolic Disease held in Bethesda, Maryland, October 19-20, 1981 / editors: Robert J. Desnick, Donald F. Patterson, Dante G. Scarpelli. Source: Wellcome Collection.

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    Progress in Clinical and Biological Research Volume 94 ANIMAL MODELS OF INHERITED METABOLIC DISEASES Robert J. Desnick, Donald F. Patterson, and Dante G. Scarpelli, Editors Most inborn errors of metabolism have been considered to be the result of homozygosity of autosomal genes carried in the heterozygous state by apparently normal individuals. Unfortunately, it is not always possible to identify these heterozy gous carriers through the study of the affected indi viduals. In such circumstances the availability of appropriate models may be invaluable. Insights gained from animal models have helped man to better understand human diseases, thereby helping to combat them, or at times even eliminate them. Animal Models of Inherited Metabolic Diseases is an in-depth study of animal models covering a large range of information from current uses to pos sible future uses. This book provides new insights into the nature of animal as well as human diseases. It is antici pated that the study of animal models will provide further insights into the molecular pathology of humans. Animal Models of Inherited Metabolic Diseases is divided into nine main chapters, the first of which is concerned with the genetic basis of diseases. Chapter two discusses detection of ani mal models of human disease. Chapter three deals with animal models of lysosomal storage diseases. Chapter four covers inborn errors of connective and epidermal tissues, while chapter five is concerned with inborn errors of immune function and histo compatibility. Inborn errors of hormone action is covered in chapter six, and chapter seven deals with other animal models systems and considera tions. The final two chapters are a compendium of inherited metabolic diseases in animals and a summary. Topics of interest include mouse models of human thalassemia, screening for inborn errors of metabolism in dogs and cats, animal models of col lagen disease, immunodeficiency disease in ani mals, H-Y antigen and sex determination in ani mals, inherited disorders of hormone resistance, and masking of mutant metabolic phenotypes by prenatal maternal influences. Animal Models of Inherited Metabolic Dis eases will be of value to all general, medical, and human geneticists, veterinarians, molecular and cel lular biologists, and zoologists, as well as those working in the fields of biochemistry and pathology.